Structural and in vitro in vivo evaluation for taste masking

Al-kasmi, Basheer; Rahal, Okba Al; El-Zein, Hind; Nattouf, Abdulhakim

doi:10.1080/17425247.2018.1535590

Cited by 11 publications

(5 citation statements)

References 84 publications

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“…Aliquots of 5 mL of solution samples were withdrawn for 5 min for phosphate buffer pH 6.8 and 2 hours for hydrochloric acid, and an equal volume of the fresh medium with the same temperature was added immediately. The aliquot samples were immediately ltered through a 0.22 µm membrane and quanti ed on a HPLC-UV system 20,21 .…”

Section: Methodsmentioning

confidence: 99%

Preparation and in vitro evaluation for amorphous solid dispersion of azithromycin

Alsayad

Laham

2023

Preprint

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The present work aimed to formulate azithromycin as amorphous solid dispersion for bitter taste masking, improving stability in an acid medium, and reducing the side effects. Solid dispersion with pH-dependent polymers (Eudragit L100, Eudragit S100) were prepared by the solvent evaporation method. The influence of polymer and drug-polymer ratio on production yields and loading% were evaluated. The F2 (AZI: L100 1:4) that gave the highest yield and loading (96 ± 0.3, 92.3 ± 0.07 respectively) was examined using Scanning electron microscopy (SEM), Fourier transform infrared (FT‑IR), Powder X‑ray diffraction (PXRD) and Differential scanning calorimetry (DSC). Taste masking evaluation was performed in vitro by two methods (in vitro drug release at saliva pH, and comparison of bitter taste threshold with the optimal formulation). (FT‑IR) study displayed that there was no interaction happen between azithromycin and Eudragit L100. DSC and PXRD emphasized the conversion of azithromycin from the crystalline to the amorphous form and entrapped inside the solid dispersion. In vitro, taste assessment detected no azithromycin release in salvia pH (6.8) within 5 min and minimal release in pH 1.2 which indicate this method might be a suitable approach to achieve taste masking of AZI and to improve stability in acid conditions.

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Section: Methodsmentioning

confidence: 99%

Preparation and in vitro evaluation for amorphous solid dispersion of azithromycin

Alsayad

Laham

2023

Preprint

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“…In vitro methods can generally be divided into electronic tongue measurements and drug release testing (36,92). Electronic tongues or e-tongues are sensory array systems that can detect individual substances or mixtures by sensor membranes and electrochemical techniques (93).…”

Section: Evaluation Of Taste Maskingmentioning

confidence: 99%

Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs

Simšič,

Planinšek,

Baumgartner

2024

Acta Pharmaceutica

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In the past, the administration of medicines for children mainly involved changes to adult dosage forms, such as crushing tablets or opening capsules. However, these methods often led to inconsistent dosing, resulting in under- or overdosing. To address this problem and promote adherence, numerous initiatives, and regulatory frameworks have been developed to develop more child-friendly dosage forms. In recent years, multiparticulate dosage forms such as mini-tablets, pellets, and granules have gained popularity. However, a major challenge that persists is effectively masking the bitter taste of drugs in such formulations. This review therefore provides a brief overview of the current state of the art in taste masking techniques, with a particular focus on taste masking by film coating. Methods for evaluating the effectiveness of taste masking are also discussed and commented on. Another important issue that arises frequently in this area is achieving sufficient dissolution of poorly water-soluble drugs. Since the simultaneous combination of sufficient dissolution and taste masking is particularly challenging, the second objective of this review is to provide a critical summary of studies dealing with multiparticulate formulations that are tackling both of these issues.

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“…Despite the importance of the FT-IR and DSC tests to confirm formulation solid dispersion, subsequent success tastes masked. However, it is very important to ensure that this technique and materials do not affect the rate and space of drug release, subsequently achieving a desirable therapeutic effect [25]. So this test was done using USP apparatus 2 (paddle), 900 ml HCl (0.1 N) dissolution medium, setting the speed at 100rpm, the temperature at 37±0.5 Cº, and 5ml samples were withdrawn after specified intervals [22].…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

SHAHOUD,

ABDLWAHED,

HAMMAD

2023

jrp

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Structural and in vitro in vivo evaluation for taste masking

Cited by 11 publications

References 84 publications

Preparation and in vitro evaluation for amorphous solid dispersion of azithromycin

Preparation and in vitro evaluation for amorphous solid dispersion of azithromycin

Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs

Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

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