Structural and mechanical characterization of crosslinked and sterilised nanocellulose-based hydrogels for cartilage tissue engineering

Al‐Sabah, Ayesha; Burnell, Stephanie E.A.; Simões, Irina N.; Jessop, Zita M.; Badiei, Nafiseh; Blain, Emma Jane; Whitaker, Iain S.

doi:10.1016/j.carbpol.2019.02.057

Cited by 77 publications

(49 citation statements)

References 53 publications

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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate nasal tissue engineering 8‐24,98‐106 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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“…Finally, the mechanical features of hydrogels can be measured by compressive stress/ strain studies and getting stress (kPa)-strain (%) curves. From this curves, tensile and ultimate strength, elongation at break, and Young s modulus applying linear regression can be measured [70]. It must be pointed out that in mechanical tests, preparation of the sample is very important, the since the samples to be tested must have always the same geometry (length × width × thickness) so that the obtained results can be comparable between them.…”

Section: Thermal and Mechanical Characterizationmentioning

confidence: 99%

Injectable Hydrogels: From Laboratory to Industrialization

Alonso¹,

Olmo²,

González³

et al. 2021

Polymers

127

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The transfer of some innovative technologies from the laboratory to industrial scale is many times not taken into account in the design and development of some functional materials such as hydrogels to be applied in the biomedical field. There is a lack of knowledge in the scientific field where many aspects of scaling to an industrial process are ignored, and products cannot reach the market. Injectable hydrogels are a good example that we have used in our research to show the different steps needed to follow to get a product in the market based on them. From synthesis and process validation to characterization techniques used and assays performed to ensure the safety and efficacy of the product, following regulation, several well-defined protocols must be adopted. Therefore, this paper summarized all these aspects due to the lack of knowledge that exists about the industrialization of injectable products with the great importance that it entails, and it is intended to serve as a guide on this area to non-initiated scientists. More concretely, in this work, the characteristics and requirements for the development of injectable hydrogels from the laboratory to industrial scale is presented in terms of (i) synthesis techniques employed to obtain injectable hydrogels with tunable desired properties, (ii) the most common characterization techniques to characterize hydrogels, and (iii) the necessary safety and efficacy assays and protocols to industrialize and commercialize injectable hydrogels from the regulatory point of view. Finally, this review also mentioned and explained a real example of the development of a natural hyaluronic acid hydrogel that reached the market as an injectable product.

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“…The methods for terminal sterilization of medical devices are categorized by FDA as established sterilization methods, which include dry heat, ethylene oxide, moist heat or steam, radiation (e.g., gamma, electron beam), all of which have a long history of safe and effective use, as demonstrated by multiple sources of information [ 86 ]. In research projects of cartilage regeneration, some biomaterials are disinfected with ultraviolet rays [ 87 ], but it is sometimes ineffective and not ideal for opaque materials due to its limited penetrability [ 88 ]. Besides, it is categorized as a novel sterilization method, and additional information is required to be provided, as compared to established methods, including a comprehensive description of the sterilization process, the validation protocol, and the sterilization validation data [ 86 ].…”

Section: Technology Overviewmentioning

confidence: 99%

“…The properties of biomaterials are obtained through precise design, and different materials have different corresponding sterilization methods [ 89 ], which may have different side-effects on the material properties. There is research showing that moist heat and steam is the optimal method to ensure sterilization efficiency, but sometimes it will result in structural alterations for biomaterials used for cartilage regeneration [ 87 ]. Different sterilization methods have their corresponding applications.…”

Section: Technology Overviewmentioning

confidence: 99%

Key considerations on the development of biodegradable biomaterials for clinical translation of medical devices: With cartilage repair products as an example

Wang

Guo

Chen

et al. 2022

Bioactive Materials

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With the interdisciplinary convergence of biology, medicine and materials science, both research and clinical translation of biomaterials are progressing at a rapid pace. However, there is still a huge gap between applied basic research on biomaterials and their translational products - medical devices, where two significantly different perspectives and mindsets often work independently and non-synergistically, which in turn significantly increases financial costs and research effort. Although this gap is well-known and often criticized in the biopharmaceutical industry, it is gradually widening. In this article, we critically examine the developmental pipeline of biodegradable biomaterials and biomaterial-based medical device products. Then based on clinical needs, market analysis, and relevant regulations, some ideas are proposed to integrate the two different mindsets to guide applied basic research and translation of biomaterial-based products, from the material and technical perspectives. Cartilage repair substitutes are discussed here as an example. Hopefully, this will lay a strong foundation for biomaterial research and clinical translation, while reducing the amount of extra research effort and funding required due to the dissonance between innovative basic research and commercialization pipeline.

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Structural and mechanical characterization of crosslinked and sterilised nanocellulose-based hydrogels for cartilage tissue engineering

Cited by 77 publications

References 53 publications

Tissue engineering applications in otolaryngology—The state of translation

Tissue engineering applications in otolaryngology—The state of translation

Injectable Hydrogels: From Laboratory to Industrialization

Key considerations on the development of biodegradable biomaterials for clinical translation of medical devices: With cartilage repair products as an example

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