Structural and some medicinal characteristics of the copper(II)–hydroxychloroquine complex

Manning, Thomas J.; Leggett, Thomas; Jenkins, Dustin; Furtado, Ivan; Phillips, Dennis; Wylie, Greg; Bythell, Benjamin J.; Zhang, Fengli

doi:10.1016/j.bmcl.2013.05.041

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…First-and second-line antibiotics were repurposed attacking the microbe with an additional antagonist [Cu(II)] and accelerating its cellular processes with an energy source [20,21]. We have used a similar repurposing approach with cancer drugs using sucrose and glucose to provide additional energy to the cancer cells, copper to increase the concentration of a limiting nutrient in the angiogenesis process and the inclusion of fatty acids and proteins to provide nutrients and increase the serum lifetime [22][23][24]. We have also been exploring an ocean-centered synthesis of bryostatin and explored many of the chemical reactions possible in this environment [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

Manning

Thomas-Richardson

Cowan

et al. 2020

Drug Discovery Today

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This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.

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Section: Discussionmentioning

confidence: 99%

Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

Manning

Thomas-Richardson

Cowan

et al. 2020

Drug Discovery Today

Self Cite

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Molecular designing, crystal structure determination and in silico screening of copper(II) complexes bearing 8-hydroxyquinoline derivatives as anti-COVID-19

Ali

Sepay

Afzal

et al. 2021

Bioorganic Chemistry

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The pandemic by COVID-19 is hampering everything on the earth including physical and mental health, daily life and global economy. At the moment, there are no defined drugs, while few vaccines are available in the market to combat SARS-CoV-2. Various molecules, mainly organic, designed and tested for the virus but they are unable to preformed accordingly. In this work we designed two copper complexes from the ligands analogues with chloroquine and hydroxychloroquine. We have synthesized and characterized them with the help of multiple spectroscopy and X-ray crystallography. The complexes are screened through in silico method with the chloroquine and hydroxychloroquine and found the target protein and mechanism of action of these organic molecules as well as complexes. The results indicate that the balanced hydrophobic and polar groups in the complexes favor their binding in the active site of the viral ADP-ribose-1 monophosphatase enzyme over the parent organic molecules.

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Copper ion as a delivery platform for taxanes and taxane complexes

Manning

Phillips

Wylie

et al. 2014

Bioorganic & Medicinal Chemistry Letters

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Structural and some medicinal characteristics of the copper(II)–hydroxychloroquine complex

Cited by 10 publications

References 21 publications

Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

Molecular designing, crystal structure determination and in silico screening of copper(II) complexes bearing 8-hydroxyquinoline derivatives as anti-COVID-19

Copper ion as a delivery platform for taxanes and taxane complexes

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