Structural and spectroscopic studies of Au(III) and Pd(II) chloride complexes and organometallics with 2-benzylpyridine

Niedzielska, Daria; Pawlak, T.; Bozejewicz, Maria; Wojtczak, Andrzej; Pazderski, Leszek; Szłyk, Edward

doi:10.1016/j.molstruc.2012.08.005

Cited by 17 publications

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References 57 publications

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“…Several strategies are being developed to fight against cancer [15][16][17]. Cis-Pt(II) complex is the first number of platinum-containing anti-cancer drug [18]. Despite greatly effective in treating the Al-Adilee & Dakheel / Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes … 2 / 17 various types of cancers, cis-Pt(II) complex has the number of side-effects such as nephrotoxicity, neurotoxicity and ototoxicity etc [19,20].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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New heterocyclic azo-schiff base dye (L2) have been synthesized from a reaction of 4-(dimethylamino)benzaldehyde with (E)-5-((1H-benzo[d]imidazol-2-yl) diazenyl) -2amine-4,6-dimethylpyridin (L1) . A new class of Ni(II), Pd(II), and Pt(IV) complexes of azo-schiff base of the type [Ni(L2)2Cl2], [Pd(L2) Cl2] , and [Pt-2amine-4,6-dimethylpyridin. Both ligand and its metal complexes were characterized by the spectroscopic and analytical methods such as mass spectral, 1 H-NMR, FT-IR, UV-Visb.,X-ray, TGA and SEM, elemental analysis, molar conductance measurements and magnetic susceptibility., spectral studies suggest the mole ratio [M:L] was [1:2] for Ni(II) and Pt(IV) metal ions, but [1:1] for Pd(II) metal ion. The structures of theses complexes were elucidated on the basis of different techniques suggest the structures of the prepared metal complexes octahedral geometry for the Ni(II) and Pt(IV) complexes and square planar geometry for the Pd(II) complex. The antibacterial activity of the ligand and prepared metal complexes was also studied against gram positive Staphylococcus aureus and gram negative bacteria Escherichia coli, the antifungal activity of the azo-schiff base and metal complexes against the fungi Alternaria. It is found that some of the complexes are quite effective against fungi Alternaria. In this study the cytotoxicity of Pd(II)-complex on human (PC3) cancer and normal cells were studied using MTT assay. Pd(II)-complex showed selective cytotoxicity against cancer cell line with IC50 = 450 μg/ml, while it was very safe on normal cells line with IC50 = 14554885 μg /ml, respectively for human cells .The results indicate undoubtedly the possibility of using them as antitumor drugs in the field of medicine and Pharmacy against prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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“…e review of NMR data for some other d 8 [23], 2bzpy [13,24], and 2-(1-methylbenzyl)pyridine [25]) two distinct rotamers were observed by 1 H NMR, even at ambient conditions. Most likely, in case of trans-[Pd(2bz � py) 2 Cl 2 ] the steric hindrance allows for one stable conformation only, analogous to that known from the solid phase (CCDC 782241 [7]), that is, with phenyl rings in both 2bz � py molecules positioned at the largest distance.…”

Section: Resultsmentioning

confidence: 99%

“…Most likely, in case of trans-[Pd(2bz � py) 2 Cl 2 ] the steric hindrance allows for one stable conformation only, analogous to that known from the solid phase (CCDC 782241 [7]), that is, with phenyl rings in both 2bz � py molecules positioned at the largest distance. [11,13]). However, H(6) deshielding is larger than in both latter complexes (Δ H (6) coord : 0.22-0.39 ppm versus 0.15 ppm and 0.14 ppm [11,13]).…”

Section: Resultsmentioning

confidence: 99%

“…[11,13]). However, H(6) deshielding is larger than in both latter complexes (Δ H (6) coord : 0.22-0.39 ppm versus 0.15 ppm and 0.14 ppm [11,13]). , where they were variously affected (mean Δ H(3)−H (6) coord : −0.04 ppm and 0.10 ppm, both in CDCl 3 [11,13]).…”

Section: Resultsmentioning

confidence: 99%

“…In the past, we studied 1 H, 13 C, and 15 N NMR spectroscopic properties of some Au(III) and Pd(II) chloride complexes and organometallics with 2-phenylpyridine (2ppy: [Au(2ppy)Cl 3 ], trans-and cis-[Pd(2ppy) 2 Cl 2 ], [Au(2ppy * )Cl 2 ] [11,12]), using 1 H- 13 C and 1 H- 15 N HMQC/HMBC. Very recently, we have applied the same NMR techniques for analogous compounds…”

Section: Introductionmentioning

confidence: 99%

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¹H,¹³C, and¹⁵N NMR Studies of Au(III) and Pd(II) Chloride Complexes and Organometallics with 2-Acetylpyridine and 2-Benzoylpyridine

Niedzielska

Pawlak

Czubachowski

et al. 2013

Journal of Spectroscopy

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Au(III) and Pd(II) chloride complexes with N(1),O-chelating 2-acetylpyridine (2apy) and N(1)- monodentately binding 2-benzoylpyridine (2bz′py)-[Pd(2apy)Cl2], [Au(2bz′py)Cl3],trans-[Pd(2bz′py)2Cl2], as well as Au(III) chloride organometallics with monoanionic forms of 2apy or 2bz′py, deprotonated at the acetyl or benzyl side groups (2apy*, 2bz′py*)-[Au(2apy*)Cl2], [Au(2bz′py*)Cl2], were studied by1H,13C, and15N NMR.1H,13C, and15N coordination shifts (i.e., differences between the respective , , and chemical shifts of the same atom in the complex and ligand molecules: , , ) were discussed in relation to the molecular structures and coordination modes, as well as to the factors potentially influencing nuclear shielding. Analogous NMR measurements were performed for the new (2bz′pyH)[AuCl4] salt.

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15N and 31P NMR Coordination Shifts in Transition Metal Complexes with Nitrogen- and Phosphorus-Containing Heterocycles

Pazderski

2013

Annual Reports on NMR Spectroscopy

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Structural and spectroscopic studies of Au(III) and Pd(II) chloride complexes and organometallics with 2-benzylpyridine

Cited by 17 publications

References 57 publications

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

¹H,¹³C, and¹⁵N NMR Studies of Au(III) and Pd(II) Chloride Complexes and Organometallics with 2-Acetylpyridine and 2-Benzoylpyridine

15N and 31P NMR Coordination Shifts in Transition Metal Complexes with Nitrogen- and Phosphorus-Containing Heterocycles

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Structural and spectroscopic studies of Au(III) and Pd(II) chloride complexes and organometallics with 2-benzylpyridine

Cited by 17 publications

References 57 publications

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

1H,13C, and15N NMR Studies of Au(III) and Pd(II) Chloride Complexes and Organometallics with 2-Acetylpyridine and 2-Benzoylpyridine

15N and 31P NMR Coordination Shifts in Transition Metal Complexes with Nitrogen- and Phosphorus-Containing Heterocycles

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¹H,¹³C, and¹⁵N NMR Studies of Au(III) and Pd(II) Chloride Complexes and Organometallics with 2-Acetylpyridine and 2-Benzoylpyridine