Structural Basis for Hyperpermeability of Tumor Vessels in Advanced Lung Adenocarcinoma Complicated by Pleural Effusion

Translational Research in Pleural Infection and Beyond

“…Over 1500 people per million population develop an exudative pleural effusion a year; pleural infection and malignant pleural effusion (MPE) being the leading causes. Active plasma extravasation from juxtapleural hyperpermeable blood vessels is a cardinal mechanism of effusion development 29,[37][38][39][40][41][42][43] and has been shown in animal models of various pleural effusions [44][45][46][47][48][49][50] .…”

“…In addition to NF-κB, other transcription activation pathways are activated in pleural diseases, such as signal transducer and activator of transcription (Stat) 3, Notch, and phosphoinositide 3-kinase/protein kinase B, which may also present marked targets for therapy 59,60,63,70 . adhesion between adjacent endothelial cells, rendering the local vasculature leaky to plasma but also blood cells 38,43 .…”

Intra‐epithelially entrapped blood vessels in ameloblastoma

“…As there are no pericyte‐specific markers, alpha‐smooth muscle actin (α‐sma) is used to identify these contractile cells that encircle the abluminal endothelial wall . Collagen IV is a major component of vascular basement membrane . To measure angiogenesis, quantitation of microvessel density (MVD) is widely used .…”

“…Collagen IV is a major component of vascular basement membrane . To measure angiogenesis, quantitation of microvessel density (MVD) is widely used .…”

Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood–Brain Barrier Disruption after Controlled Cortical Impact in Mice: An18F-Fluorodeoxyglucose PET/CT Study

“…31 In our study, we found that CCI induced angiogenesis and that COG1410 treatment decreased BBB permeability and brain edema while improving vestibulomotor deficits by partially suppressing angiogenesis in the acute stage. These outcomes might result from a structurally defective neovascularization 32 and excessive cerebral perfusion pressure (CPP), which is increased by excessive angiogenesis, exacerbates extravasation of components, and aggravates brain edema. 25 Johanson and coworkers reported that VEGF not only enhanced angiogenesis, but also could increase permeability and place a patient at risk of hemorrhaging in the early stage.…”