Structural, biochemical and immunochemical characterization of an acidic phospholipase A2 from Lachesis acrochorda (Viperidae: Crotalinae) venom

Franco-Vásquez, Adrián Marcelo; Lazcano-Pérez, Fernando; Mejía-Sánchez, Miguel Angel; Corzo, Gerardo; Zamudio, Fernando; Carbajal-Saucedo, Alejandro; Román-González, Sergio Agustín; Gómez-Manzo, Saúl; Arreguín-Espinosa, Roberto

doi:10.1016/j.toxicon.2023.107528

Cited by 1 publication

(1 citation statement)

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“…Its venom mainly comprises 35.1% of SVSPs, 23.2% of SVMPs, 21.2% of VAPs, 7.9% of CTLs, 2.3% of PLA 2 s, 2.7% of LAAOs, and 1.8% of CRISPs [ 29 , 80 ]. Only one compound is characterized by this venom, a PLA 2 named Lacro_PLA 2 of about 13.97 kDa, involved in edema and myonecrosis effects from the venom [ 81 ].…”

Section: Viperidae Familymentioning

confidence: 99%

Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis

Chang Estrada,

Guerrero,

Reyes-Enríquez

et al. 2024

Toxins

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Central America is home to one of the most abundant herpetofauna in the Americas, occupying only 7% of the continent’s total area. Vipers and lizards are among the most relevant venomous animals in medical practice due to the consequences of envenomation from the bite of these animals. A great diversity of biomolecules with immense therapeutic and biotechnological value is contained in their venom. This paper describes the prominent leading representatives of the family Viperidae, emphasizing their morphology, distribution, habitat, feeding, and venom composition, as well as the biotechnological application of some isolated components from the venom of the animals from these families, focusing on molecules with potential anti-thrombotic action. We present the leading protein families that interfere with blood clotting, platelet activity, or the endothelium pro-thrombotic profile. In conclusion, Central America is an endemic region of venomous animals that can provide many molecules for biotechnological applications.

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Section: Viperidae Familymentioning

confidence: 99%