Structural Brain Abnormalities of Attention-Deficit/Hyperactivity Disorder With Oppositional Defiant Disorder

Noordermeer, Siri D. S.; Luman, Marjolein; Greven, Corina U.; Veroude, Kim; Faraone, Stephen V.; Hartman, Catharina A.; Hoekstra, Pieter J.; Franke, Barbara; Buitelaar, Jan K.; Heslenfeld, Dirk J.; Oosterlaan, Jaap

doi:10.1016/j.biopsych.2017.07.008

Cited by 55 publications

(74 citation statements)

References 51 publications

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“…Some studies have investigated the effect of symptom presentation and comorbidities (especially oppositional defiant disorder and conduct disorder) in order to determine disorder specific abnormalities, but more studies are required to elicit clear‐cut conclusions.…”

Section: Structural Brain Imaging In Adhdmentioning

confidence: 99%

Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder

Sáenz

Villemonteix

Massat

2018

Develop Med Child Neuro

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Over the last decade, there has been a dramatic increase in the number of neuroimaging studies in attention‐deficit/hyperactivity disorder (ADHD). In terms of brain structure, magnetic resonance imaging (MRI), and diffusion tensor imaging studies have evidenced differences in volume, surface‐based measures (cortical thickness, surface area, and gyrification), and white matter integrity in different cerebral regions, in children and adults with ADHD compared to population norms. Abnormalities in the basal ganglia, prefrontal structures, and the corpus callosum have been the most consistently reported findings across studies. Hemodynamic (functional MRI, functional near‐infrared spectroscopy, positron emission tomography, single‐photon emission computed tomography) and magnetoencephalography measurements have also shown differences in neural activity during the execution of neuropsychological tasks and during rest, in widespread regions of the brain. Importantly, multimodal studies combining structural and functional methods have shown an intercorrelation between structural and functional abnormalities in ADHD. Further longitudinal studies are needed to clarify the effects of age and medication on brain structure and function in individuals with ADHD. What this paper adds In attention‐deficit/hyperactivity disorder (ADHD), the brain is characterized by abnormal neural network interplay. Structural and functional cerebral abnormalities in ADHD are intercorrelated. Currently there is no neural biomarker that can be used in diagnosis. Longitudinal studies have shed light on the brain correlates of ADHD over the lifespan. The effects of stimulant intake on the brain correlates of ADHD remain unclear.

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Section: Structural Brain Imaging In Adhdmentioning

confidence: 99%

Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder

Sáenz

Villemonteix

Massat

2018

Develop Med Child Neuro

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“…Interestingly, some recent studies did not assess (Greven et al, 2015;Hoogman et al, 2017) or did not find cerebellum alterations (Noordermeer et al, 2017; for a meta-analysis see also Frodl & Skokauskas, 2012), while others showed increased gray matter concentration of the cerebellum in CD (De Brito et al, 2009). Interestingly, some recent studies did not assess (Greven et al, 2015;Hoogman et al, 2017) or did not find cerebellum alterations (Noordermeer et al, 2017; for a meta-analysis see also Frodl & Skokauskas, 2012), while others showed increased gray matter concentration of the cerebellum in CD (De Brito et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Future studies are needed, that disentangle the specific contribution of ODD versus CD (Noordermeer et al, 2016;Noordermeer et al, 2017) and systematically compare ADHDonly, ADHD with comorbid ODD or with comorbid CD and the pure forms of ODD and CD. Due to the small size of the ADHD+ODD/CD-group, we could not differentiate between ODD and CD alterations.…”

Section: Discussionmentioning

confidence: 99%

Altered brain morphology in boys with attention deficit hyperactivity disorder with and without comorbid conduct disorder/oppositional defiant disorder

Vetter

Backhausen

Buse

et al. 2019

Human Brain Mapping

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About 50% of attention deficit hyperactivity disorder (ADHD) patients suffer from comorbidity with oppositional defiant disorder/conduct disorder (ODD/CD). Most previous studies on structural morphology did not differentiate between pure (ADHD-only) and comorbid ADHD (ADHD+ODD/CD). Therefore, we aimed to investigate the structural profile of ADHD-only versus ADHD+ODD/CD spanning the indices subcortical and cortical volume, cortical thickness, and surface area. We predicted a reduced total gray matter, striatal, and cerebellar volume in both patient groups and a reduced amygdalar and hippocampal volume for ADHD+ODD/CD. We also explored alterations in prefrontal volume, thickness, and surface area. We acquired structural images from an adolescent sample ranging from 11 to 17 years, matched with regard to age, pubertal status, and IQ-including 36 boys with ADHDonly, 26 boys with ADHD+ODD/CD, and 30 typically developing (TD) boys. We analyzed structural data with FreeSurfer. We found reductions in total gray matter and total surface area for both patient groups. Boys with ADHD+ODD/CD had a thicker cortex than the other groups in a right rostral middle frontal cluster, which was related to stronger ODD/CD symptoms, even when controlling for ADHD symptoms.No group differences in local cortical volume or surface area emerged. We demonstrate the necessity to carefully differentiate between ADHD and ADHD+ODD/CD. The increased rostral middle frontal thickness might hint at a delayed adolescent cortical thinning in ADHD+ODD/CD. Patients with the double burden ADHD and ODD or CD seem to be even more affected than patients with pure ADHD. K E Y W O R D SADHD, adolescence, conduct disorder, FreeSurfer, oppositional defiant disorder, structural morphology, structural MRI † Shared senior-authorship.

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“…Further complicating this is the unclear impact of comorbidities on neuroanatomical differences seen in ADHD (10). In their neuroimaging study addressing this question, Noordermeer et al.…”

mentioning

confidence: 99%

“…In their neuroimaging study addressing this question, Noordermeer et al. (10) showed that a group of participants with ADHD/oppositional defiant disorder had greater volumetric reductions in frontal regions than an ADHD-only group. They therefore suggested that the overlap of affected regions between commonly comorbid disorders may create a structural “double burden” in those areas.…”

mentioning

confidence: 99%

Shifting Focus: From Group Patterns to Individual Neurobiological Differences in Attention-Deficit/Hyperactivity Disorder

Lenet

2017

Biological Psychiatry

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Structural Brain Abnormalities of Attention-Deficit/Hyperactivity Disorder With Oppositional Defiant Disorder

Cited by 55 publications

References 51 publications

Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder

Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder

Altered brain morphology in boys with attention deficit hyperactivity disorder with and without comorbid conduct disorder/oppositional defiant disorder

Shifting Focus: From Group Patterns to Individual Neurobiological Differences in Attention-Deficit/Hyperactivity Disorder

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