Structural brain alterations in patients with major depressive disorder and high risk for suicide: Evidence for a distinct neurobiological entity?

Wagner, Gerd; Koch, Kathrin; Schachtzabel, Claudia; Schultz, C. Christoph; Sauer, Heinrich; Schlößer, R.

doi:10.1016/j.neuroimage.2010.08.082

Cited by 208 publications

(120 citation statements)

References 48 publications

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“…In addition, ACC volume depletion appears to have meaningful associations with psychopathological and neuropsychological features that are relatively specific for MDD. Reduced ACC volume was found to be associated with attention biases towards negative, depressionrelated cues (Leung et al, 2009), with a diminished ability to down-regulate negative -but not positive -emotions (Mak et al, 2009), with worse executive performance (Vasic et al, 2008), and with higher risk for suicidal behavior (Wagner et al, 2011). Lastly, ACC volume decrease was found to correlate with negative antidepressant treatment response in cross-sectional imaging studies of MDD (Chen et al, 2007;Gunning et al, 2009).…”

Section: Discussionmentioning

confidence: 93%

Specificity of abnormal brain volume in major depressive disorder: A comparison with borderline personality disorder

Depping

Wolf

Vasić³

et al. 2015

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 93%

Specificity of abnormal brain volume in major depressive disorder: A comparison with borderline personality disorder

Depping

Wolf

Vasić³

et al. 2015

Journal of Affective Disorders

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“…These studies identified widespread differences across frontal, temporal and parietal lobes (Hwang et al, 2010, Wagner et al, 2012). Suicidality is associated with smaller volumes of the anterior cingulate cortex (Wagner et al, 2011, Wagner, Schultz, 2012, Willeumier et al, 2011), insula (Soloff et al, 2012, Willeumier, Taylor, 2011), orbitofrontal cortex (OFC) (Monkul et al, 2007, Soloff, Pruitt, 2012), and dorsolateral prefrontal cortex (Wagner, Schultz, 2012). Reductions in perfusion and metabolism are also observed in many of these regions (Willeumier, Taylor, 2011).…”

Section: Introductionmentioning

confidence: 99%

Widespread white matter but focal gray matter alterations in depressed individuals with thoughts of death

Taylor

Boyd

McQuoid

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Background Past work demonstrates that depressed individuals with suicidal thoughts or behaviors exhibit specific neuroanatomical alterations. This may represent a distinct phenotype characterized by specific findings on neuroimaging, but it is unclear if these findings extend to individuals with milder thoughts of death. We examined this question in outpatients with recurrent Major Depressive Disorder not receiving antidepressant treatment. Methods We examined 165 subjects: 53 depressed without thoughts of death, 21 depressed with thoughts of death, and 91 healthy comparison subjects. Participants completed 3T cranial MRI, including anatomical and diffusion tensor imaging acquisitions. Automated methods measured regional gray matter volumes in addition to cortical thickness. White matter analyses examined diffusion measures within specific fiber tracts and included voxelwise comparisons. Results After adjustment for multiple comparisons, the depressed group with thoughts of death did not exhibit differences in regional gray matter volume, but did exhibit reduced cortical thickness in frontoparietal regions and the insula. This depressed group with thoughts of death also exhibited widespread white matter differences in fractional anisotropy and radial diffusivity. These differences were observed primarily in posterior parietal white matter regions and central white matter tracts adjacent to the basal ganglia and thalamus. Conclusions Mild thoughts of death are associated with structural alterations in regions of the salience network, default mode network, and thalamocortical circuits. Further work is needed to understand the pathological basis of these findings.

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“…Indeed, hyper-responsiveness of this region has been shown to correlate with subclinical depressive mood in adolescent children (Killgore & Yurgelun-Todd, 2006). It is important to note that in addition to ACC abnormalities, other areas found to have reduced gray matter volume within MDD subjects in the above-mentioned meta-analyses include the middle and inferior frontal gyrus, hippocampus and thalamus (Kim et al 2008; Vasic et al 2008; Zou et al 2010; Wagner et al 2011; Du et al 2012), as well as the DLPFC and dorsomedial prefrontal cortex (Bora et al 2012). Given that the thalamus connects the cortex to negative emotion-generating limbic structures such as the amygdala (Price & Drevets, 2009), relatively reduced thalamic gray matter volume may help account for deficits in top-down regulation of negative affect among individuals more prone to experiencing depressive symptoms.…”

Section: Introductionmentioning

confidence: 99%

Reduced gray matter volume in the anterior cingulate, orbitofrontal cortex and thalamus as a function of mild depressive symptoms: a voxel-based morphometric analysis

et al. 2014

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Background Studies investigating structural brain abnormalities in depression have typically employed a categorical rather than dimensional approach to depression [i.e. comparing subjects with Diagnostic and Statistical Manual of Mental Disorders (DSM)-defined major depressive disorder (MDD) v. healthy controls]. The National Institute of Mental Health, through their Research Domain Criteria initiative, has encouraged a dimensional approach to the study of psychopathology as opposed to an over-reliance on categorical (e.g. DSM-based) diagnostic approaches. Moreover, subthreshold levels of depressive symptoms (i.e. severity levels below DSM criteria) have been found to be associated with a range of negative outcomes, yet have been relatively neglected in neuroimaging research. Method To examine the extent to which depressive symptoms – even at subclinical levels – are linearly related to gray matter volume reductions in theoretically important brain regions, we employed whole-brain voxel-based morphometry in a sample of 54 participants. Results The severity of mild depressive symptoms, even in a subclinical population, was associated with reduced gray matter volume in the orbitofrontal cortex, anterior cingulate, thalamus, superior temporal gyrus/temporal pole and superior frontal gyrus. A conjunction analysis revealed concordance across two separate measures of depression. Conclusions Reduced gray matter volume in theoretically important brain regions can be observed even in a sample that does not meet DSM criteria for MDD, but who nevertheless report relatively elevated levels of depressive symptoms. Overall, these findings highlight the need for additional research using dimensional conceptual and analytic approaches, as well as further investigation of subclinical populations.

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Structural brain alterations in patients with major depressive disorder and high risk for suicide: Evidence for a distinct neurobiological entity?

Cited by 208 publications

References 48 publications

Specificity of abnormal brain volume in major depressive disorder: A comparison with borderline personality disorder

Specificity of abnormal brain volume in major depressive disorder: A comparison with borderline personality disorder

Widespread white matter but focal gray matter alterations in depressed individuals with thoughts of death

Reduced gray matter volume in the anterior cingulate, orbitofrontal cortex and thalamus as a function of mild depressive symptoms: a voxel-based morphometric analysis

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