Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury

Qiukuan, Wang; Song, Yu; He, Yueqiu; Ren, Dazhong; Kow, F; Qiao, Zhiyong; Liu, Shu; Yu, Xingju

doi:10.1016/j.carbpol.2014.02.071

Cited by 52 publications

(24 citation statements)

References 32 publications

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“…The broad band centered at 3435 cm -1 assigned to hydrogen bonded O-H stretching vibration. [28][29][30] The band at 2939 cm -1 was attributed the C-H stretching pyranoid ring and C6 of fucose and/or galactose units. 13,30 The band at 1614 cm -1 indicated the stretching of asymmetric carboxylate O-C-O vibration.…”

Section: Resultsmentioning

confidence: 99%

“…[28][29][30] The band at 2939 cm -1 was attributed the C-H stretching pyranoid ring and C6 of fucose and/or galactose units. 13,30 The band at 1614 cm -1 indicated the stretching of asymmetric carboxylate O-C-O vibration. 28,29 The band at 1424 cm -1 suggested C-OH deformation vibration with contribution of O-C-O symmetric stretching vibration of carboxylate group.…”

Section: Resultsmentioning

confidence: 99%

“…29 The presence of O=S=O stretching vibration of sulphate esters was indicated by a band at 1258 cm-113, 28,29 The band at 1040 cm -1 corresponded to stretching vibration of C-O-C/C-OH. 30 The band at 820 cm -1 assigned the C-O-S bending vibration of sulfate group. [28][29][30][31] The band at 580 cm -1 indicated the asymmetric and symmetric O=S=O deformation of sulfate.…”

Section: Resultsmentioning

confidence: 99%

“…30 The band at 820 cm -1 assigned the C-O-S bending vibration of sulfate group. [28][29][30][31] The band at 580 cm -1 indicated the asymmetric and symmetric O=S=O deformation of sulfate. 31 These FT-IR spectra analysis proved that the extraction and purification processes used and purification process used in this study were effective to obtain fucoidan from the three tropical brown algae.…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines

Isnansetyo¹,

Lutfia²,

Nursid³

et al. 2016

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Introduction:Fucoidan is a sulfated polysaccharide that has a wide range of bioactivities including anti-cancer. This polysaccharide commonly is extracted from marine brown seaweed. There is lack of information on the fucoidan extracted from tropical brown algae and its anti-cancer activity. Objectives: The objectives of this study were to purify fucoidan from Sargassum sp., Turbinaria sp. and Padina sp., and to evaluate their cytotoxicity against breast cancer (MCF-7) and colon cancer cells (WiDr). Materials and Methods: Fucoidan extraction was conducted by using acid extraction method. Purified fucoidans were obtained by DEAE cellulose column chromatography and confirmed by HPLC and FT-IR spectrometry. The cytotoxicity was evaluated by using the MTT (3-[4,5-dimethylthiazol-2-yl] -2,5-diphenyltetrazolium bromide) assay. Results: Fucoidan from Sargassum sp. and Turbinaria sp. showed low cytotoxicity with IC 50 ranging between 461-663 µg/mL. Higher cytotoxicity against MCF-7 and WiDr was showed by fucoidan from Padina sp. with IC 50 of 144 and 118 µg/mL, respectively. While its IC 50 against Vero cells was 501 µg/mL.Standard fucoidan from Fucus vesiculosus exhibited IC 50 of 60, 63 and 211 µg/mL against MCF-7, WiDr and Vero Cells, respectively. Although the IC 50 was higher than that of standard fucoidan, Padina sp. fucoidan showed cytotoxicity comparable with standard fucoidan at concentrations below 100 µg/mL. Conclusion: These results indicated that Padina sp.fucoidan showed potential selective cytotoxicity, and promising for the development of an anti-cancer compound.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines

Isnansetyo¹,

Lutfia²,

Nursid³

et al. 2016

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“…CC is a brown algae species belonging to the genus Costaria and the family Costariaceae, distributed across the sea of Korea, China, and Japan [16]. Although recent studies have established several biological activities of various marine algae [17, 18], only a few studies have reported the biological effects of CC in cancer and CCL4-induced liver injury [19, 20]. In our previous study, CC extract suppressed the production of proinflammatory cytokines and Th2 cytokines in HaCaT cells, and primary splenocytes and histamine in MC/9 cells [21].…”

Section: Introductionmentioning

confidence: 99%

<b><i>Costaria costata</i></b> Extract Suppresses Development of Atopic Dermatitis in chloro-2,4-dinitrobenzene-treated NC/Nga Mice

Kim¹,

Lee²,

Kwon³

et al. 2018

Skin Pharmacol Physiol

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We investigated the potential effects of Costaria costata (CC) on atopic dermatitis (AD) development in chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. CC is a brown alga distributed across the seas of Korea, China, and Japan. A total of 40 mice were randomly assigned to 5 groups with 8 mice per group: untreated Balb/c mice, AD control (0.1% w/v DNCB-treated NC/Nga mice), positive control (i.e., DNCB-treated NC/Nga mice fed a dietary supplement of 66.6 mg/kg of body weight [b.w.] of CJLP133), DNCB-treated NC/Nga mice fed a dietary supplement of 100 mg/kg b.w. of CCE10 (CCE10 100), and DNCB-treated mice fed a dietary supplement of 300 mg/kg b.w. of CCE10 (CCE10 300) groups. The CCE10 100 and CCE10 300 treatment groups suppressed AD development including clinical and histopathological changes and a reduction in skin hydration induced by DNCB. In addition, Th2 cytokine production in primary splenocytes, serum IgE and histamine production, and mast cell infiltration into the skin were suppressed in the CCE10 300 mice compared to the CCE10 100 mice. Our finding demonstrated an inhibitory effect of CCE10 in AD development by means of improving the Th1/Th2 cytokine balance and anti-inflammatory effect in an in vivo model.

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Antioxidant and Antibacterial Activities of Polysaccharides

Mohan¹,

Thirupathi²

2021

Polysaccharides of Microbial Origin

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Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury

Cited by 52 publications

References 32 publications

Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines

Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines

<b><i>Costaria costata</i></b> Extract Suppresses Development of Atopic Dermatitis in chloro-2,4-dinitrobenzene-treated NC/Nga Mice

Antioxidant and Antibacterial Activities of Polysaccharides

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