Structural characterization and biological activities of polysaccharide iron complex synthesized by plant polysaccharides: A review

Abstract

Iron deficiency anemia can lead to a variety of functional disorders, which is one of the highest incidence of nutrient deficiency diseases. The direct addition of iron to food will not only brings difficulties to the production of products, but also brings damages to human body. In recent years, international studies have shown that polysaccharide iron complex (PIC) not only has a variety of pharmacological activities of polysaccharide itself, but also has the function of supplementing iron, so it is a good iron supplement. With the advantages of good solubility, high iron content, low gastrointestinal irritation and high bioavailability, PIC is an effective iron supplement for iron deficiency anemia and has attracted more and more attention. In this paper, the different preparation methods, structural characterization, biological activities and clinical applications of PIC synthesized by natural polysaccharides from plant were reviewed, in order to provide theoretical basis for the development and application of PIC.

Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes

“…95,96 IPCs, which are isolated from plants or chemically synthesized, are composed of a polysaccharide carrier complexed with ferric iron atoms and have variable structures and physiochemical properties. 96 IPC formulations have been evaluated for use in correcting IDA. 15,16 In a seminal study, IPC was compared to FeSO 4 (both used at 3 mg iron/ kg body weight, once daily) for restoring Hb levels in infants and young children with nutritional IDA.…”

Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

“…Therefore PIC has been widely used in clinical practice. [ 84 ] PIC is mainly used to treat various diseases accompanied by ischemia, such as internal medicine IDA, chemotherapy, cancer, elderly IDA, pregnancy IDA, children's IDA, and renal anemia in chronic kidney failure dialysis patients, etc. Below will be some examples of PIC application in clinical practice.…”

Preparation, characterization, antioxidant and antianemia activities of Poria cocos polysaccharide iron (III) complex

“…The first generation of iron supplements are mainly inorganic iron compounds, of which Fe 2 SO 4 is the most commonly used. Although iron content is high in the first generation of iron supplements, there are severe gastrointestinal irritation and other adverse effects [ 3 ]. The second generation of iron supplements are mainly soluble small molecule organic iron salts represented by ferrous lactate, ferrous gluconate, etc.…”

“…The second generation of iron supplements are mainly soluble small molecule organic iron salts represented by ferrous lactate, ferrous gluconate, etc. Although the adverse reactions were reduced, problems such as iron instability also exist [ 3 ]. Therefore, many researchers are committed to developing the third generation of macromolecular iron complexes, such as polypeptide iron chelate, heme iron, and polysaccharide iron, etc.…”