Structural characterization of a new cobalt(II) complex of 1-benzyl-5-methyl-1H-imidazole

Bouchouit, Mehdi; Bouraiou, Abdelmalek; Bouacida, Sofiane; Belfaitah, Ali; Mérazig, Hocine

doi:10.1134/s0022476616040338

Cited by 6 publications

(1 citation statement)

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“…Two polymorphs of the compound {Co(bmim) 2 Cl 2 } ( 1 ) have been experimentally obtained and characterised. The crystal structure of the first polymorph was discussed in our previous work 34 . The second polymorph of 1 , described herein, crystallises in a monoclinic crystal system (space group P2 1 /c) and is characterised as a tetra-coordinate metal complex ( Figure 1(a) ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes

Bouchouit

Bouacida

Zouchoune

et al. 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

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Three coordination compounds of formula {M(bmim)2Cl2} were synthetised (M = Co, Zn, and Hg) and fully characterised. Each complex incorporates 1-benzyl-2-methylimidazole (bmim) as ligand. The coordination polyhedron around the metal center for all complexes has a quasi-regular tetragonal geometry. Density functional theory calculations were carried out on the title compounds and as well on hypothetical complexes (Cu, Ni), in order to elucidate their electronic and molecular structure. The calculations reproduced the Co, Zn, and Hg experimental structures and could predict stable complexes in the case of Ni(II) and Cu(II) ions. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the three complexes were investigated. Only compound {Hg(bmim)2Cl2} (3) exhibited a modest inhibitory effect against hCA I, probably due to the affinity of Hg(II) for His residues at the entrance of the active site cavity.

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Section: Resultsmentioning

confidence: 99%