Structural characterization of ginseng cyclopeptides and detection of capability to induce apoptosis in gastrointestinal cancer cells

Gastric cancer is a malignant tumor that originates from the epithelium of the gastric mucosa. It is the result of a combination of multiple factors, but the current research has not yet clarified its pathogenesis, so further research and exploration are needed. This article is mainly based on the meta-analysis of the improvement of gastrointestinal tumor-related symptoms and prognosis based on medical care and exercise intervention. The control group followed routine care after enrollment. In addition to routine care, patients in the intervention group exercised through assessment, formulation of exercise prescriptions, implementation of supervision, and adjustment. By viewing the subjects' physical examination reports, determine their blood routine, urine routine, blood lipids, blood sugar, liver and kidney function, and electrocardiogram examination. In this experiment, dual-contrast ultrasound in each T staging was greater than 0.8, indicating that the diagnostic method is very accurate in the preoperative diagnosis of gastric cancer T staging. The results show that exercise intervention can improve the pain of patients with gastrointestinal tumors after chemotherapy, relieve cancer-induced fatigue, and improve the quality of life.

show abstract

“…Healthcare. Assuming that the random variable X obeys the logistic distribution, the cumulative distribution function of X is as follows [4,5]:…”

Section: Exercise Intervention and Gastrointestinal Tumorsmentioning

confidence: 99%

Meta-Analysis on the Improvement of Symptoms and Prognosis of Gastrointestinal Tumors Based on Medical Care and Exercise Intervention

Wang

Shi

2021

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…Seven novel ginseng cyclopeptides (GCPs) were isolated and showed anti-proliferative activities in gastric cancer SGC-7901 cells, in which GCP-1 (86) showed the most potency with IC 50 value of 37.8 µM. Regarding its molecular mechanism, it induces apoptosis by activating the caspases and regulating thioredoxin (Trx)-dependent pathways, including signal-regulating kinase 1 (ASK1), mitogen-activated protein kinases (MAPKs)-p38 and JNK pathways [138].…”

Section: Terrestrial Plant-derived Anticancer Cyclopeptidesmentioning

confidence: 99%

“…[ [181][182][183][184][185] Ohmyungsamycins A (121) and B (122) Streptomyces sp. [196] Sungsanpin (138) Streptomyces sp. Anti-invasion effects on A549 cell.…”

Section: Anticancer Cyclopeptides Derived From Cyanobacteriamentioning

confidence: 99%

Natural Cyclopeptides as Anticancer Agents in the Last 20 Years

Zhang

Xia

Zhang

2021

IJMS

View full text Add to dashboard Cite

Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino acids. A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. Compared to linear peptides, cyclopeptides have absolute advantages of structural rigidity, biochemical stability, binding affinity as well as membrane permeability, which contribute greatly to their anticancer potency. Therefore, the discovery and development of natural cyclopeptides as anticancer agents remains attractive to academic researchers and pharmaceutical companies. Herein, we provide an overview of anticancer cyclopeptides that were discovered in the past 20 years. The present review mainly focuses on the anticancer efficacies, mechanisms of action and chemical structures of cyclopeptides with natural origins. Additionally, studies of the structure–activity relationship, total synthetic strategies as well as bioactivities of natural cyclopeptides are also included in this article. In conclusion, due to their characteristic structural features, natural cyclopeptides have great potential to be developed as anticancer agents. Indeed, they can also serve as excellent scaffolds for the synthesis of novel derivatives for combating cancerous pathologies.

show abstract

“…The Royal Society of Chemistry hereby wholly retracts this RSC Advances article due to a significant amount of unattributed text overlap with articles by different author groups, including articles published in Acta Pharmacologica Sinica by Yu-ping Zhu et al 1 and RSC Advances by Zhuo Liu et al 2 …”

mentioning

confidence: 99%

Retraction: Structural characterization of Mesobuthus martensii Karsch peptides and anti-inflammatory potency evaluation in human vascular endothelial cells

Fisher

2022

RSC Adv.

View full text Add to dashboard Cite

show abstract

Structural characterization of ginseng cyclopeptides and detection of capability to induce apoptosis in gastrointestinal cancer cells

Abstract: Gastrointestinal tumors are the most frequently diagnosed malignancy and the second highest contributor to cancer mortality.

Cited by 4 publications

References 26 publications

Meta-Analysis on the Improvement of Symptoms and Prognosis of Gastrointestinal Tumors Based on Medical Care and Exercise Intervention

Meta-Analysis on the Improvement of Symptoms and Prognosis of Gastrointestinal Tumors Based on Medical Care and Exercise Intervention

Natural Cyclopeptides as Anticancer Agents in the Last 20 Years

Retraction: Structural characterization of Mesobuthus martensii Karsch peptides and anti-inflammatory potency evaluation in human vascular endothelial cells

Contact Info

Product

Resources

About