Structural clusters of histone H3 and H4 residues regulate chronological lifespan inSaccharomyces cerevisiae

Abstract

18We have performed a comprehensive analysis of the involvement of histone H3 and H4 19 residues in the regulation of chronological lifespan in yeast, and identify four structural 20 groups in the nucleosome that influence lifespan. We also identify residues where 21 substitution with an epigenetic mimic extends lifespan, providing evidence that a simple 22