Structural connectome alterations in prodromal and de novo Parkinson's disease patients

Wen, Ming‐Ching; Heng, Hannah S. E.; Hsu, Jung-Lung; Xu, Zheyu; Liew, Gerald; Au, Wing Lok; Chan, Ling‐Ling; Tan, Louis; Tan, Eng King

doi:10.1016/j.parkreldis.2017.09.019

Cited by 34 publications

(67 citation statements)

References 35 publications

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“…Our study revealed no correlation between DTI measure and risk scores, such as sniffin' sticks and RBDSQ. This is in contrast to previous studies on PD-RP revealing structural correlates of olfactory tests (Wen et al, 2017;Heldmann et al, 2018) as well as RBDSQ (Wen et al, 2017). This is may be due to the lower prevalence of these risk factors in our PD-RP cohort.…”

Section: Discussioncontrasting

confidence: 99%

“…It is worth mentioning that PD-RP did not differ from the control group in regards to their TMT performance. While other imaging studies also failed to demonstrate cognitive deficits in PD-RP (Wen et al, 2017;Heldmann et al, 2018), a recent review reported the existence of executive function impairments in prodromal PD (Fengler et al, 2017). Hence, prospective longitudinal studies are still needed to determine the role of cognitive changes as a reliable biomarker for prodromal PD.…”

Section: Discussionmentioning

confidence: 99%

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Distinct Relationship Between Cognitive Flexibility and White Matter Integrity in Individuals at Risk of Parkinson’s Disease

Alzaid

Ethofer

Hobert

et al. 2020

Front. Aging Neurosci.

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Background and Objective: Executive dysfunction is the most common cognitive impairment in Parkinson's disease (PD), occurring even in its early stages. In our study, we applied diffusion tensor imaging (DTI) to investigate white matter integrity and its association with a specific executive function such as cognitive flexibility in individuals with risk factors for PD. Methods: We examined 50 individuals with risk factors for developing PD and 24 healthy controls from the TREND (Tübinger Evaluation of Risk Factors for Early Detection of Neurodegeneration) study including neuropsychological evaluation and DTI. Cognitive flexibility was assessed using the trail making test (TMT). Tract based spatial statistics (TBSS) were employed to assess white matter abnormalities and their correlation with cognitive flexibility. Results: TMT performance correlated with mean and axial diffusivity in several white matter regions, predominantly in the frontoparietal white matter. These effects were stronger in PD risk persons (PD-RP) than in controls as evidenced by a significant group interaction. White matter integrity and TMT performance did not significantly differ across groups. Conclusion: Based on our results, PD-RP do no exhibit white matter changes or impaired cognitive flexibility. However, specific executive functions in PD-RP are more related to white matter alterations than in healthy older adults.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distinct Relationship Between Cognitive Flexibility and White Matter Integrity in Individuals at Risk of Parkinson’s Disease

Alzaid

Ethofer

Hobert

et al. 2020

Front. Aging Neurosci.

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“…Accordingly, increased network efficiency and connectivity has been shown in prodromal phases, followed by decreased local connectivity in symptomatic phases, suggesting the emergence and dissipation of neural compensation [50].…”

Section: Discussionmentioning

confidence: 99%

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia

Tsvetanov

Gazzina

Jones

et al. 2019

Preprint

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INTRODUCTION: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial Frontotemporal dementia (FTD). METHODS: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. RESULTS: There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviourally-relevant structural and functional network differences. Structure-function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease. DISCUSSION: Our findings suggest that maintenance of functional network connectivity enables carriers to maintain cognitive performance.

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“…35 Promising techniques include 11 C-donepezil PET/CT (cholinergic (parasympathetic) gut innervation), 123 I-metaiodobenzylguanidine scintigraphy (cardiac sympathetic denervation), 36 susceptibility-weighted and neuromelanin-sensitive MRI (dorsal nigral hyperintensity; integrity of pigmented neurons of the locus coeruleus), 11 Cmethylreboxetine PET (noradrenergic nerve terminals originating in the locus coeruleus), structural connectivity and functional MRI (striatal or whole-brain function). 35,[37][38][39] However, for the establishment of prodromal (neuro)imaging markers consensus on specific methods and analyses is needed. 3.…”

Section: Promising Candidate Markersmentioning

confidence: 99%

Update of the MDS research criteria for prodromal Parkinson's disease

et al. 2019

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The MDS Research Criteria for Prodromal PD allow the diagnosis of prodromal Parkinson's disease using an evidence‐based conceptual framework, which was designed to be updated as new evidence becomes available. New prospective evidence of predictive values of risk and prodromal markers published since 2015 was reviewed and integrated into the criteria. Many of the predictive values (likelihood ratios, LR) remain unchanged. The positive likelihood ratio notably increase for olfactory loss and decreased for substantia nigra hyperechogenicity. Negative likelihood ratio remained largely unchanged for all markers. New levels of diagnostic certainty for neurogenic and symptomatic orthostatic hypotension have been added, which substantially differ in positive likelihood ratio from the original publication. For intermediate strength genetic variants, their age‐related penetrance is now incorporated in the calculation of the positive likelihood ratio. Moreover, apart from prospective studies, evidence from cross‐sectional case‐control genome‐wide association studies is also considered (given their likely lack of confounding and reverse causation), and to account for the effect of multiple low‐penetrance genetic variants polygenic risk scores are added to the model. Diabetes, global cognitive deficit, physical inactivity, and low plasma urate levels in men enter the criteria as new markers. A web‐based prodromal PD risk calculator allows the calculation of probabilities of prodromal PD for individuals. Several promising candidate markers may improve the diagnostic accuracy of prodromal PD in the future. © 2019 International Parkinson and Movement Disorder Society

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Structural connectome alterations in prodromal and de novo Parkinson's disease patients

Cited by 34 publications

References 35 publications

Distinct Relationship Between Cognitive Flexibility and White Matter Integrity in Individuals at Risk of Parkinson’s Disease

Distinct Relationship Between Cognitive Flexibility and White Matter Integrity in Individuals at Risk of Parkinson’s Disease

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia

Update of the MDS research criteria for prodromal Parkinson's disease

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