Structural control and biomedical applications of plasmonic hollow gold nanospheres: A mini review

Guarino-Hotz, Melissa; Zhang, Jin Z.

doi:10.1002/wnan.1694

Cited by 11 publications

(8 citation statements)

References 99 publications

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“…Among many nano-scale materials, hollow gold nanoparticles (HAuNP) have become an excellent candidate for drug delivery due to their cavity structure, high availability of internal and external surfaces, good biosafety, biocompatibility, and functional capabilities [112]. The surface plasmon absorption band of HAuNP can be adjusted by adjusting the inner diameter and thickness of the gold shell from visible light to near-infrared.…”

Section: Pdt Combined With Chemotherapymentioning

confidence: 99%

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

et al. 2021

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Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing transient levels of reactive oxygen species (ROS). Compared with free photosensitizers, the use of nanoparticles in PDT shows great advantages in terms of solubility, early degradation, and biodistribution, as well as more effective intercellular penetration and targeted cancer cell uptake. Under the current circumstances, researchers have made promising efforts to develop nanocarrier photosensitizers. Reasonably designed photosensitizer (PS) nanoparticles can be achieved through non-covalent (self-aggregation, interfacial deposition, interfacial polymerization or core-shell embedding and physical adsorption) or covalent (chemical immobilization or coupling) processes and accumulate in certain tumors through passive and/or active targeting. These PS loading methods provide chemical and physical stability to the PS payload. Among nanoparticles, metal nanoparticles have the advantages of high stability, adjustable size, optical properties, and easy surface functionalization, making them more biocompatible in biological applications. In this review, we summarize the current development and application status of photodynamic therapy for breast cancer, especially the latest developments in the application of metal nanocarriers in breast cancer PDT, and highlight some of the recent synergistic therapies, hopefully providing an accessible overview of the current knowledge that may act as a basis for new ideas or systematic evaluations of already promising results.

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Section: Pdt Combined With Chemotherapymentioning

confidence: 99%

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

et al. 2021

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“…59 The HGNs benefit from the enhancement of the EM field by both the interior and exterior surfaces. 20 With the addition of the spikes, the relative enhancement factor increased by 3 orders of magnitude, which can be explained by the increase in the number of active binding sites for the analyte molecules and by the antenna effect of the spikes. 51 The relative enhancement factor shown here is an order of magnitude higher than previously reported HNSs, 59 likely due to the increased amount of silver, causing an increased spike tip Finally, with the addition of a silver layer to the HNSs, AgHNSs exhibit a 5630-fold enhancement from HGNs.…”

Section: ■ Results and Discussionmentioning

confidence: 44%

Near-Infrared Light Absorbing Silver-Coated Hollow Gold Nanostars for Surface-Enhanced Raman Scattering Detection of Bovine Serum Albumin Using Capping Ligand Exchange

et al. 2022

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Two novel urchinlike plasmonic nanostructures, hollow gold nanostars (HNSs) and silver-coated hollow gold nanostars (AgHNSs), were synthesized using hollow gold nanospheres (HGNs) as templates. The particle morphology was assessed by transmission electron microscopy (TEM), optical properties were characterized by UV–vis spectroscopy, and elemental composition was evaluated by both inductively coupled plasma-optical emission spectrometry (ICP-OES) and energy-dispersive X-ray (EDX) analysis. Both the HNSs and AgHNSs exhibit tunable structural and optical properties. Their unique star-shaped structure provides the desired “hot spots” for enhancing the electromagnetic (EM) field for surface-enhanced Raman scattering (SERS) applications, while their near-infrared (NIR) absorption is ideal for biomedical applications. A comparative analysis of the relative SERS enhancement using rhodamine 6G (R6G) showed that HNSs reported herein have an order of magnitude higher relative enhancement over previously reported HNSs. Moreover, AgHNSs have a 4-fold increase in the SERS signal compared to HNSs. Discrete dipole approximation (DDA) simulations of electric field enhancement were used to corroborate the experimental findings. The comparison between the experimental and theoretical results suggests that the significant increase in SERS enhancement cannot be completely explained by the larger dielectric constant of silver. The branching of individual spikes, or the increased binding efficacy of the analyte to the nanoparticles, likely also plays an important role. To further explore the applicability of these novel structures, successful capping ligand exchange from citrate to pentanethiol was used to switch the surface charge from negative to positive to facilitate the SERS detection of dried bovine serum albumin (BSA). AgHNSs are stable and effective NIR-absorbing substrates for SERS detection of biological samples. Elemental analyses of AgHNSs, in conjunction with DDA simulations, provide insights into their enhancement mechanism.

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“…NPS have witnessed a large spectrum of applications nowadays. One of the most important is their use as a diagnostic tool for example by functionalizing the surface of NPs (e.g., gold NPs) with biological matter such as antibodies that can detect the presence of certain proteins correlated to a given disease [158]. In addition, NPs have become a center of attention because of their magnetic properties, such as iron oxide considered as superparamagnetic NPs.…”

Section: Why Are Nps a Center Of Attention Today?mentioning

confidence: 99%

Biomaterials for Three-Dimensional Cell Culture: From Applications in Oncology to Nanotechnology

et al. 2021

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Three-dimensional cell culture has revolutionized cellular biology research and opened the door to novel discoveries in terms of cellular behavior and response to microenvironment stimuli. Different types of 3D culture exist today, including hydrogel scaffold-based models, which possess a complex structure mimicking the extracellular matrix. These hydrogels can be made of polymers (natural or synthetic) or low-molecular weight gelators that, via the supramolecular assembly of molecules, allow the production of a reproducible hydrogel with tunable mechanical properties. When cancer cells are grown in this type of hydrogel, they develop into multicellular tumor spheroids (MCTS). Three-dimensional (3D) cancer culture combined with a complex microenvironment that consists of a platform to study tumor development and also to assess the toxicity of physico-chemical entities such as ions, molecules or particles. With the emergence of nanoparticles of different origins and natures, implementing a reproducible in vitro model that consists of a bio-indicator for nano-toxicity assays is inevitable. However, the maneuver process of such a bio-indicator requires the implementation of a repeatable system that undergoes an exhaustive follow-up. Hence, the biggest challenge in this matter is the reproducibility of the MCTS and the associated full-scale characterization of this system’s components.

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Structural control and biomedical applications of plasmonic hollow gold nanospheres: A mini review

Cited by 11 publications

References 99 publications

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

Near-Infrared Light Absorbing Silver-Coated Hollow Gold Nanostars for Surface-Enhanced Raman Scattering Detection of Bovine Serum Albumin Using Capping Ligand Exchange

Biomaterials for Three-Dimensional Cell Culture: From Applications in Oncology to Nanotechnology

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