Structural Diversity, Electrochemical, and DNA-Binding Properties of Copper(II) Carboxylates

Iqbal, Muhammad; Ali, Saqib; Haider, Ali; Khalid, Nasir

doi:10.1007/s40995-016-0141-5

Cited by 5 publications

(3 citation statements)

References 95 publications

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“…Besides the electrostatic arguments, the geometric conformation also matters. 39,40 Unlike the above mentioned Cu complexes, which are square pyramidal, the [Cu(2CP-Bz-SMe)] 2+ complex has a distorted trigonal bipyramidal geometry. We hypothesize such conformation may allow the phenanthroline fragments to be better accommodated into the double helix.…”

Section: Dna Binding Studiesmentioning

confidence: 99%

Synergy of DNA intercalation and catalytic activity of a copper complex towards improved polymerase inhibition and cancer cell cytotoxicity

et al. 2021

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Section: Dna Binding Studiesmentioning

confidence: 99%

Synergy of DNA intercalation and catalytic activity of a copper complex towards improved polymerase inhibition and cancer cell cytotoxicity

et al. 2021

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“…Therefore the Cu-Cu bond can't exist in such dinuclear Cu(II) complexes. 30 The supramolecular structure of the complex 2 has been given in Fig. 4 showing that the molecules are held together through weak Br⸱⸱⸱H-C and O⸱⸱⸱H-C type linkages.…”

Section: Crystal Structure Descriptionmentioning

confidence: 99%

Binuclear copper(II) complexes: Synthesis, structural characterization, DNA binding and in silico studies

Kamran

Ali

Tahir

et al. 2020

JSCS

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Two new binuclear Cu(II) complexes represented by the general formula {(dmso)Cu(µ-L)4Cu(dmso)} (1) and {(Phen)(L)Cu(µ-L)2Cu(L)(Phen)} (2) where dmso = dimethyl sulphoxide, L = 2-bromophenyl acetate and Phen = 1,10-phenanthroline have been synthesized, isolated quantitatively and characterized by UV/Visible and FT-IR spectroscopic techniques, Thermogravimetry/Differential Thermal Analysis and X-ray single crystal XRD studies. Complex 1 is paddlewheel with 1,2-O,O-bridging while 2 has 1,1-O-bridging. The values of the intrinsic binding constants with DNA were found out to be 2.0×10 3 and 1.1×10 3 M -1 , respectively for compound 1 and 2. The mode of interaction of complexes with DNA was also evaluated through computational study by molecular docking (in silico) study using MOE (molecular operating environment) software. The synthesized complexes are structurally as well as biologically important.

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“…For these reasons, there is no bond between the copper centers in a paddlewheel unit and the geometry of each copper ion is square pyramidal if the copper is axially coordinated by another ligand. 2 If both copper ions of the paddlewheel unit are coordinated axially by monodentate ligands, the resulting structure is a discrete paddlewheel molecule. 3 However, there are complexes having interlinked paddlewheel units in which the binuclear units are trans-interlinked via copper, oxygen or both atoms by intervening ligands.…”

Section: Introductionmentioning

confidence: 99%

A binary copper(II) complex having stepped polymeric structure: Synthesis, characterization, DNA-binding and anti-fungal studies

et al. 2020

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A rarely found polymeric complex of copper(II) was obtained in the reaction of 2-(4-methylphenyl)acetate and copper sulfate and crystallized in quantitative yield. The complex was characterized using FT-IR, electron spin resonance, absorption spectroscopy, electrochemistry and powder and single crystal XRD studies. The structure was found to consist of interconnected paddlewheel units without an intervening ligand resulting in a stepped polymeric arrangement of the structure. The purity of the sample was judged from powder XRD data while ESR spectroscopy indicated a weak signal between 3000 and 4000 G values, indicating the presence of Cu(II) in the complex. Electrochemistry revealed an irreversible, predominantly diffusion controlled Cu II Cu II / /Cu II Cu I process with a D 0 value calculated to be 3.032×10-8 cm 2 s-1. The complex was screened for its DNA-binding ability through cyclic voltammetry, absorption and florescence spectroscopy and viscometry; the former two yielding K b values of 3.34×10 3 and 6.90×10 3 M-1 , respectively. The complex exhibited significant activity against fungal strain Mucor piriformis, moderate activity against Aspergillus niger and slight activity against Helminthosporium solani. These preliminary findings revealed the excellent biological potential of the synthesized complex.

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Structural Diversity, Electrochemical, and DNA-Binding Properties of Copper(II) Carboxylates

Cited by 5 publications

References 95 publications

Synergy of DNA intercalation and catalytic activity of a copper complex towards improved polymerase inhibition and cancer cell cytotoxicity

Synergy of DNA intercalation and catalytic activity of a copper complex towards improved polymerase inhibition and cancer cell cytotoxicity

Binuclear copper(II) complexes: Synthesis, structural characterization, DNA binding and in silico studies

A binary copper(II) complex having stepped polymeric structure: Synthesis, characterization, DNA-binding and anti-fungal studies

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