Structural Elucidation and Activities of Cordyceps militaris-Derived Polysaccharides: A Review

Miao, Miao; Yu, Wenqian; Li, Yuan; Sun, Yanlong; Guo, Shoudong

doi:10.3389/fnut.2022.898674

Cited by 30 publications

(6 citation statements)

References 121 publications

(218 reference statements)

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“…Polysaccharides isolated from plants and fungi also exhibit powerful lipid-lowering effects as reviewed recently by distinct groups ( 179 , 180 ). Cyclocarya paliurus -, Saussurea involucrata -, Astragalus membranaceus -, and Cordyceps militaris -derived polysaccharides exert therapeutic effects in hyperlipidemic rats partially via upregulating PPARα/CPT signaling pathway ( 181 – 184 ).…”

Section: Natural Compounds In Regulation Of Pparsmentioning

confidence: 99%

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Zhang,

Shi

et al. 2024

Front. Cardiovasc. Med.

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Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and control the expression of multiple genes that are involved in lipid metabolism and inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. Natural products are structural diversity and have a good safety. Recent studies find that natural herbs and compounds exhibit attractive therapeutic effects on atherosclerosis by alleviating hyperlipidemia and inflammation through modulation of PPARs. Importantly, the preparation of natural products generally causes significantly lower environmental pollution compared to that of synthesized chemical compounds. Therefore, it is interesting to discover novel PPAR modulator and develop alternative strategies for atherosclerosis therapy based on natural herbs and compounds. This article reviews recent findings, mainly from the year of 2020 to present, about the roles of natural herbs and compounds in regulation of PPARs and their therapeutic effects on atherosclerosis. This article provides alternative strategies and theoretical basis for atherosclerosis therapy using natural herbs and compounds by targeting PPARs, and offers valuable information for researchers that are interested in developing novel PPAR modulators.

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Section: Natural Compounds In Regulation Of Pparsmentioning

confidence: 99%

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Zhang,

Shi

et al. 2024

Front. Cardiovasc. Med.

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“…Researchers have investigated the glycosidic bond configuration within Cordyceps polysaccharides. The arrangement of these chemical bonds can influence their biological activity [23].…”

Section: Compositionmentioning

confidence: 99%

Medicinal Properties of Honey and Cordyceps Mushrooms

Badea,

Vamanu

2023

Nutraceuticals

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In a world still recovering after the COVID-19 pandemic, the consequences of which are still not entirely known, the attention of scientists worldwide is drawn to natural products with positive effects on immunity. The starting point for tackling such a subject is proper documentation of substances used in traditional medicine, which usually have significant nutritional and functional values. Among the most well-known of these substances are mushrooms and honey, both of which have been used for thousands of years all around the globe. The following work aims to gather information about the properties of honey and Cordyceps sp. mushrooms by studying the scientific literature available at this point. With the proper use of this information, it will be possible to develop products that incorporate the studied ingredients to increase their functional and medicinal value.

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“…Numerous studies have shown that molecular weight [66], monosaccharide composition and ratio [67], glycoside bond type [68], and grading structure [69] can influence the immune activity of HPS. An excessively high molecular weight can reduce the exposure of the active sites on HPS, thus limiting their bioactivity.…”

Section: Immunomodulatory Activity Of Hpsmentioning

confidence: 99%

Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy

et al. 2022

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Herb polysaccharides (HPS) have been studied extensively for their healthcare applications. Though the toxicity was not fully clarified, HPS were widely accepted for their biodegradability and biocompatibility. In addition, as carbohydrate polymers with a unique chemical composition, molecular weight, and functional group profile, HPS can be conjugated, cross-linked, and functionally modified. Thus, they are great candidates for the fabrication of drug delivery systems (DDS). HPS-based DDS (HPS-DDS) can bypass phagocytosis by the reticuloendothelial system, prevent the degradation of biomolecules, and increase the bioavailability of small molecules, thus exerting therapeutic effects. In this review, we focus on the application of HPS as components of immunoregulatory DDS. We summarize the principles governing the fabrication of HPS-DDS, including nanoparticles, micelles, liposomes, microemulsions, hydrogels, and microneedles. In addition, we discuss the role of HPS in DDS for immunotherapy. This comprehensive review provides valuable insights that could guide the design of effective HPS-DDS.

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Structural Elucidation and Activities of Cordyceps militaris-Derived Polysaccharides: A Review

Cited by 30 publications

References 121 publications

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Medicinal Properties of Honey and Cordyceps Mushrooms

Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy

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