Structural elucidation of two new compounds from Artemisia ordosica and their antioxidative activity

Abstract

Two new compounds, namely, arteordosin A (1) and arteordosin B (2), were isolated from the CHCl3 extract of Artemisia ordosica. This is the first report on the structure elucidation of arteordosin A (1) and arteordosin B (2) based on spectroscopic methods including electrospray ionization mass spectrometry, one-dimensional (1D) nuclear magnetic resonance spectroscopy (NMR) and 2D NMR techniques. Antioxidant activities of the compounds were measured for their radical scavenging capacity using 2,2-diphenyl-1-picrylhydrazyl. Compound 1 (IC50 of 1.01 mg mL−1) showed antioxidant activity similar to the standard reference ascorbic acid (IC50 of 0.98 mg mL−1) and is more active than compound 2 (IC50 of 1.87 mg mL−1). In conclusion, arteordosin A (1) and arteordosin B (2) may be used as potential antihyperlipidemic agent in routine clinical practice.

Effects of <i>Artemisia ordosica</i> aqueous extract on intestinal inflammation and antioxidant-related gene expression in lipopolysaccharide-challenged broilers

“…A. ordosica contains many bioactive compounds, which encompass polyphenols, flavonoids, terpenoids, essential oil and polyacetylenes (Zhang et al, 2017;Wang et al, 2019;Zhou et al, 2019). Numerous studies have demonstrated that A. ordosica has anti-inflammatory, antimicrobial (Xiao et al, 2020;Tang et al, 2021), antioxidant (Wu et al, 2019) and immunoregulatory (Xing et al, 2019) properties. Previous reports have indicated the potential benefits of A. ordosica aqueous extract (AOE) as a natural phytogenic feed additive with antioxidant potential.…”

Bioassay-Guided Isolation of Broad-Spectrum Fungicidal Active Compound from Artemisia ordosica

“…The chemical constituents of A. ordosica are abundant and diverse, including flavonoids [ 16 ], terpenes [ 17 , 18 ], polysaccharides, sterols [ 19 ], coumarins [ 20 ], phenylpropanoids [ 17 ], organic acids, amino acids, and microelements [ 15 ]. In recent years, some compounds have been isolated, including a new lignan glycoside (artemordolignan glycoside A) [ 21 ], a new coumarin having a new skeleton (arteordocoumarin A) [ 22 ], four new compounds (arteordoyn A, arteordoyn B, arteordosin A, and arteordosin B) [ 23 , 24 ], and five polyacetylenes (capillene, capillinol, capillin, trans-dehydromatricaria ester, and cis-dehydromatricariaria ester) [ 25 ].…”

“…After isolation, some compounds and crude essential oils exhibit reasonable repellent and fumigant activity [ 25 ]. For instance, arteordosin A and B showed antioxidant activities and could be potentially used as an antihyperlipidemic agent in routine clinical practice [ 23 ]. The inhibition rates of A. ordosica acetone extract against Fusarium oxysporum, Colletotrichum lagenarium , Botrytis cinerea , and Alternaria solani were more than 70%.…”