Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina

Wang, S.C.; Bligh, S. W. Annie; Shi, Songshan; Wang, Z.T.; Zhi-bi, HU; Crowder, John; Branford-White, Christopher; Vella, Cherelyn

doi:10.1016/j.ijbiomac.2007.05.008

Cited by 81 publications

(43 citation statements)

References 31 publications

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“…Typically, marine algal extracts have low toxicity to cell cultures (Romanos et al, 2002b;Adhikari et al, 2006;Mandal et al, 2007;Wang et al, 2007;Mendes et al, 2010). Our findings point to similar results.…”

Section: Discussionsupporting

confidence: 90%

Anti-HSV activity of Hypnea musciformis cultured with different phytohormones

Mendes¹,

Bravin²,

Yoneshigue‐Valentin³

et al. 2012

Rev. bras. farmacogn.

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Four extracts from the seaweed Hypnea musciformis (Wulfen in Jacq.) J.V. Lamour. (Rhodophyta), collected directly from its natural habitat or cultivated in the presence of phytohormones, were evaluated for their ability to inhibit the replication of acyclovir-resistant herpes simplex viruses types 1 (HSV-1) and 2 (HSV-2) strains. The main purpose was to determinate whether these growth conditions would affect the antiviral activity. Our results showed the possibility of improving the anti-HSV activity by using extracts from algae cultured in the presence of phytohormones.

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Section: Discussionsupporting

confidence: 90%

Anti-HSV activity of Hypnea musciformis cultured with different phytohormones

Mendes¹,

Bravin²,

Yoneshigue‐Valentin³

et al. 2012

Rev. bras. farmacogn.

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“…On the other hand, oral administration of sulfated compounds, dextran sulfate (Abrams et al 1989) and pentosan polysulfate (Peters et al 1991), in HIVinfected individuals was reported to be less effective. The second generation of these compounds, combining more polysaccharides, was shown to be more potent in suppressing viral infection and pathogenesis (Wang et al 2007;Woolfson et al 2000). In our JEV-infected mice model, the encephalitis syndromes of JEV-infected mice developed as a result of over replication of JEV in the brain that sequentially damaged neuron cells.…”

Section: Discussionmentioning

confidence: 94%

Inhibition of Japanese Encephalitis Virus Infection by the Sulfated Polysaccharide Extracts from Ulva lactuca

Chiu

Chan

et al. 2011

Mar Biotechnol

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Japanese encephalitis virus (JEV), a neurotropic flavivirus, is one of the major causes of acute encephalitis in humans. After infection, inflammatory reactions and neurological diseases often develop. Still there are no effective drugs available against virus infection. Recently, extracts of algae have been shown to possess a broad range of biological activities including antivirus activity. In this study, we identified that the sulfated polysaccharide extracts from Ulva lactuca can inhibit JEV infection in Vero cells. Mechanistic studies further revealed that the Ulva sulfated polysaccharide extracts can block virus adsorption and thus make the virus unable to enter cells. The Ulva sulfated polysaccharide extracts also effectively decrease the production of pro-inflammatory cytokines in the JEV-infected primary mixed glia cells. In an animal study, the JEV-infected C3H/HeN mice appeared to have neurobehavioral abnormalities on the fifth day and died on the seventh day post infection. However, the JEV-infected mice pretreated with the Ulva sulfated polysaccharide extracts can delay the onset of hind limb paralysis and thereby prevent mice from death.

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“…Thus, the information obtained from one-dimensional NMR spectroscopy is limited to the relative concentrations of some of the majority components. The results showed that the activity observed in the extracts could be related to the minor components or to the concentration of the active molecules In general, the algal extracts present low toxicity for cell cultures 1,24,37,48 . The same was observed in this work.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus

Mendes

Soares

Martins

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYWe evaluated the antiviral activity of the marine alga, Ulva fasciata, collected from Rasa beach and Forno beach, Búzios, Rio de Janeiro, Brazil on the replication of human metapneumovirus (HMPV). The algae extracts were prepared using three different methodologies to compare the activity of different groups of chemical composites obtained through these different methodologies. Four out of the six extracts inhibited nearly 100% of viral replication. The results demonstrated that the majority of the extracts (five out of six) possess virucidal activity and therefore have the ability to interact with the extracellular viral particles and prevent the infection. On the other hand, only two extracts (from Forno beach, obtained by maceration and maceration of the decoction) were able to interact with cell receptors, hindering the viral entry. Finally, only the extract of algae collected at Forno beach, obtained by maceration presented intracellular activity. To our knowledge, this is a pioneer study on antiviral activity of marine algae against HMPV. It is also the first on antiviral activity against HMPV ever done in Brazil. The study also shows the effect of different environment factors and different chemical procedures used to obtain the extract on its biological properties.

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Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina

Cited by 81 publications

References 31 publications

Anti-HSV activity of Hypnea musciformis cultured with different phytohormones

Anti-HSV activity of Hypnea musciformis cultured with different phytohormones

Inhibition of Japanese Encephalitis Virus Infection by the Sulfated Polysaccharide Extracts from Ulva lactuca

Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus

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