Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

Zhao, Donghai; Zheng, Lianwen; Qi, Ling; Wang, Shuran; Guan, Liping; Xia, Yong; Cai, Jianhui

doi:10.3390/md14070123

Cited by 54 publications

(41 citation statements)

References 41 publications

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“…In that case, 30 mg/kg exerted effects similar to those of 20 mg/kg of fluoxetine on FST and TST. Finally, the effects on monoamine levels in mice brains confirm that sterols modify the serotonergic and noradrenergic systems but do not impact the dopaminergic system [93].…”

Section: Sterols With Anxiolytic and Antidepressant Effectsmentioning

confidence: 66%

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

García-Ríos¹,

Mora-Pérez²,

Ramos-Molina³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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Depression and anxiety currently rank as the second and fifth most common causes worldwide of years lived with disability-a reality that has intensified the search for new treatments. There are many studies of herbal extracts and secondary metabolites from plants used in traditional medicine due to their antidepressant and anxiolytic properties. Clinical and preclinical studies about some of the mechanisms of action of metabolites like alkaloids, terpenes, flavonoids, and sterols, among others, have documented effects similar to those produced by clinically effective drugs. These metabolites have shown anxiolytic and antidepressant effects in various experimental models of anxiety by interacting with γ-aminobutyric acid subtype A receptors (GABA A-receptors) and by stimulating the serotonergic, noradrenergic, and dopaminergic neurotransmitter systems. These pharmacological effects can be attributed to plant metabolites that share structural similarities with monoamines, which allow them to bind to receptors. The objective of this chapter is to summarize the various mechanisms of action that have been identified in secondary metabolites with anxiolytic and antidepressant properties. Terpenes, alkaloids, flavonoids, and sterols can interact at different levels of the neurotransmission systems involved in the neurobiology of anxiety and depression, suggesting their potential for treating these mental illnesses.

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Section: Sterols With Anxiolytic and Antidepressant Effectsmentioning

confidence: 66%

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

García-Ríos¹,

Mora-Pérez²,

Ramos-Molina³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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show abstract

“…Chronic treatment with the ethanol extract (50, 100, and 200 mg/kg) did not significantly inhibit brain MAO-A activity in both unstressed and stressed mice, indicating that MAO-A inhibition might not be responsible for antidepressant activity of the ethanol extract. Further, antidepressant activity of the extract might be due to the presence of beta-sitosterol, which is present in the extract to the extent of 3.68%, since antidepressant activity of beta-sitosterol has been reported in the literature [42].…”

Section: Discussionmentioning

confidence: 97%

“…In the present investigation, ethanol extract of flowers of T. undulata administered for 21 successive days showed significant antidepressantlike activity in mice subjected to CUMS. Induction of depression using CUMS is considered as the most valid animal model of depressive behavior observed in humans after long-term exposure to multiple stressors [42,43]. CUMS-induced depression model can be used for evaluating the potential antidepressants by employing behavioral tests such as TST [32] and sucrose preference test [9].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-Like Activity of Flowers of Tecomella Undulata in Mice Subjected to Chronic Unpredictable Mild Stress

Dhingra

Deepak

2019

Asian J Pharm Clin Res

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Objective: Flowers of Tecomella undulata have been reported to be a rich source of flavonoids such as rutin and quercetin. The present study was designed to evaluate the effect of ethanol extract of flowers of T. undulata on chronic unpredictable mild stress (CUMS)-induced depression in Swiss young male albino mice.Methods: The mice were subjected to CUMS for 21 successive days. Ethanol extract of the flowers (50, 100, and 200 mg/kg, p.o.) and fluoxetine (20 mg/kg, p.o.) per se was administered for 21 successive days to separate groups of unstressed and stressed mice. Tail suspension test (TST) and sucrose preference test were used to evaluate the effect of the extract on depression-like behavior in mice.Results: Extract of flowers of T. undulata (100 and 200 mg/kg) significantly decreased immobility period of stressed mice in TST, indicating significant antidepressant-like activity of the extract. Stress-induced reduced sucrose preference was significantly restored by the extract. There was no significant effect on locomotor activity of mice by the extract and fluoxetine. The extract significantly reversed stress-induced increase in brain malondialdehyde levels; plasma nitrite and corticosterone levels; and also significantly reversed the stress-induced decrease in reduced glutathione and catalase levels. There was no significant effect of the extract on brain MAO-A activity in both unstressed and stressed mice.Conclusion: These results indicated that ethanol extract of flowers of T. undulata showed significant antidepressant-like activity in mice subjected to CUMS, probably through alleviation of oxidative stress and decrease in plasma corticosterone levels.

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“…Several studies reported neuroprotective role of astaxanthin and fucoxanthin [145, [282][283][284][285][286][287], Sargassum spp. [288][289][290][291][292][293][294][295], Saccorhiza polyschide [283], Codium tomentosum [296], Ulva spp [256,267,293,[297][298][299][300], Ecklonia maxima [256,[301][302][303], Gracilaria spp. (Figure 12) [296,[304][305][306][307][308][309][310][311], Gelidium pristoides [312,313], Halimeda incrassate [314,315], Bryothamniom triquetrum [316][317][318], Chondrus crispus ( Figure 13) [319,320], Hypnea valentiae (…”

Section: Neuroprotection In Stroke Alzheimer's and Parkinsonismmentioning

confidence: 99%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

Cited by 54 publications

References 41 publications

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

Antidepressant-Like Activity of Flowers of Tecomella Undulata in Mice Subjected to Chronic Unpredictable Mild Stress

Seaweeds: An Extensive Review of Medicinal Values

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