Structural features of the Cu2+–vancomycin complex

Cu(II) ion interaction with teicoplanin-vancomycin’s analog

“…The X-ray structure of the Cu(II)-vancomycin [9] which supports the solution structure [8] indicates that position of both amide nitrogens involved in the metal ion coordination is well fitted to bind metal ion (Fig. 7).…”

“…Beside Cu(II) ions it is also able to coordinate Ru(II) ions [7]. Our recent works have shown surprisingly effective binding of Cu(II) ions to vancomycin antibiotic [8,9]. The latter unusual binding ability derives most likely from a specific peptide conformation formed by the cyclic structure comprising inserted peptide moiety.…”

“…Overlay of the Cu(II)-vancomycin complex structure (solid line)[9] with one of the monomers of free vancomycin molecule (dashed line, derived from PDB database, structure code 1AA5).…”

Crystal Structures of the Complexes between Vancomycin and Cell-Wall Precursor Analogs

“…1), providing a mechanism for ligand recognition; and (iii) dimerization enhances the binding of ligands by antibiotics. X-ray studies of vancomycin and related antibiotics have repeatedly confirmed "back-to-back" dimerization for vancomycin, [13][14][15][16][17] aglycovancomycin, 18 A-40926, 19 balhimycin, 20,21 deglucobalhimycin, 21 ureidobalhimycin, 22 and decaplanine, 23 except for monomeric degradation products such as the CDP-1 analog of vancomycin 24 and the CDP-1 analog of methylated vancomycin. 25 The formation of five hydrogen bonds between the antibiotic and the ligand has also been verified in the crystal structures of balhimycin or deglucobalhimycin complexes 21 with tripeptide or pentapeptide ligands with -D-Ala-DAla termini.…”

Simultaneous determination of heavy metal ions by caillary zone electrophoresis using a complex selector

“…В работе [22] показано, что ионы меди(II) способны образовывать прочный комплекс с ванко-мицином состава 1 : 1, взаимодействуя с атомами азота пептидной цепи молекулы. Комплексообразу-ющий фрагмент в молекуле ванкомицина содержит трипептидный блок и остаток аспарагина, при этом комплекс имеет квадратную координацию [23] (рис. 1).…”