Structural features of ultradeformable archaeosomes for topical delivery of ovalbumin

Carrer, Dolores C.; Higa, Leticia Herminia; Tesoriero, María Victoria Defain; Morilla, María José; Roncaglia, Diana I.; Romero, Eder Lilia

doi:10.1016/j.colsurfb.2014.05.015

Cited by 27 publications

(13 citation statements)

References 60 publications

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“…The epidermis of mice, pigs and apparently also humans is organized in corneocyte columns, with polygonal shapes 9,10,22 . Each column or “cluster” of cells is surrounded and separated from others by a structure called a “canyon”.…”

Section: Resultsmentioning

confidence: 99%

Liposomes can both enhance or reduce drugs penetration through the skin

Peralta

Guzmán

Perez

et al. 2018

Sci Rep

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The adequate formulation of topical vehicles to treat skin diseases is particularly complex. A desirable formulation should enhance the accumulation of the active drugs in the target tissue (the skin), while avoiding the penetration enhancement to be so large that the drugs reach the systemic circulation in toxic amounts. We have evaluated the transcutaneous penetration of three drugs chosen for their widely variable physicochemical properties: Amphotericin B, Imiquimod and Indole. We incorporated the drugs in fluid or ultra-flexible liposomes. Ultra-flexible liposomes produced enhancement of drug penetration into/through human skin in all cases in comparison with fluid liposomes without detergent, regardless of drug molecular weight. At the same time, our results indicate that liposomes can impede the transcutaneous penetration of molecules, in particular small ones.

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Section: Resultsmentioning

confidence: 99%

Liposomes can both enhance or reduce drugs penetration through the skin

Peralta

Guzmán

Perez

et al. 2018

Sci Rep

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“…After SC penetration the UDL were lipids taken up by viable skin cells. After sc administration in mice, archaeosomes compose potent adjuvants for the induction of Th1, Th2 and CD8 + T cell responses to the entrapped soluble Ag (Carrer et al, 2014). Table 2 shows some important applications of archaeosomesbased formulations.…”

Section: Uda As Topical Adjuvantmentioning

confidence: 99%

Archaeosomes: an excellent carrier for drug and cell delivery

et al. 2015

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Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.

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“…SPC is therefore unavoidable, since the mixing of EAs occurs after the TPA is diluted in a given amount of SPC. 44 It is likely, therefore, that the insertion of hydrophobic ZnPc within the TPA-SPC mixture interfered with EA demixing, decreasing its deformability.…”

Section: Znpc Concentration (µM) Ros Production (%)mentioning

confidence: 99%

Enhanced photodynamic leishmanicidal activity of hydrophobic zinc phthalocyanine within archaeolipids containing liposomes

Perez

Casasco

Schilrreff

et al. 2014

IJN

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In this work, the in vitro anti-Leishmania activity of photodynamic liposomes made of soybean phosphatidylcholine, sodium cholate, total polar archaeolipids (TPAs) extracted from the hyperhalophile archaea Halorubrum tebenquichense and the photosensitizer zinc phthalocyanine (ZnPcAL) was compared to that of ultradeformable photodynamic liposomes lacking TPAs (ZnPcUDLs). We found that while ZnPcUDLs and ZnPcALs (130 nm mean diameter and −35 mV zeta potential) were innocuous against promastigotes, a low concentration (0.01 µM ZnPc and 7.6 µM phospholipids) of ZnPcALs irradiated at a very low-energy density (0.2 J/cm 2 ) eliminated L. braziliensis amastigotes from J774 macrophages, without reducing the viability of the host cells. In such conditions, ZnPcALs were harmless for J774 macrophages, HaCaT keratinocytes, and bone marrow-derived dendritic cells. Therefore, topical photodynamic treatment would not likely affect skin-associated lymphoid tissue. ZnPcALs were extensively captured by macrophages, but ZnPcUDLs were not, leading to 2.5-fold increased intracellular delivery of ZnPc than with ZnPcUDLs. Despite mediating low levels of reactive oxygen species, the higher delivery of ZnPc and the multiple (caveolin-and clathrin-dependent plus phagocytic) intracellular pathway followed by ZnPc would have been the reason for the higher antiamastigote activity of ZnPcALs. The leishmanicidal activity of photodynamic liposomal ZnPc was improved by TPA-containing liposomes.

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Structural features of ultradeformable archaeosomes for topical delivery of ovalbumin

Cited by 27 publications

References 60 publications

Liposomes can both enhance or reduce drugs penetration through the skin

Liposomes can both enhance or reduce drugs penetration through the skin

Archaeosomes: an excellent carrier for drug and cell delivery

Enhanced photodynamic leishmanicidal activity of hydrophobic zinc phthalocyanine within archaeolipids containing liposomes

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