Structural-functional relationships between eye orbital imaging biomarkers and clinical visual assessments

Abstract

Eye diseases and visual impairment affect millions of Americans and induce billions of dollars in annual economic burdens. Expounding upon existing knowledge of eye diseases could lead to improved treatment and disease prevention. This research investigated the relationship between structural metrics of the eye orbit and visual function measurements in a cohort of 470 patients from a retrospective study of ophthalmology records for patients (with thyroid eye disease, orbital inflammation, optic nerve edema, glaucoma, intrinsic optic nerve disease), clinical imaging, and visual function assessments. Orbital magnetic resonance imaging (MRI) and computed tomography (CT) images were retrieved and labeled in 3D using multi-atlas label fusion. Based on the 3D structures, both traditional radiology measures (e.g., Barrett index, volumetric crowding index, optic nerve length) and novel volumetric metrics were computed. Using stepwise regression, the associations between structural metrics and visual field scores (visual acuity, functional acuity, visual field, functional field, and functional vision) were assessed. Across all models, the explained variance was reasonable (R2 ~ 0.1–0.2) but highly significant (p < 0.001). Instead of analyzing a specific pathology, this study aimed to analyze data across a variety of pathologies. This approach yielded a general model for the connection between orbital structural imaging biomarkers and visual function.

Orbital volume measurements from magnetic resonance images using the techniques of manual planimetry and stereology

“…[ 8 ] The described limitations force patients to undergo several imaging examinations for proper evaluation and datasets then require complex postprocessing algorithms which allow fusing and cumulative measurements. [ 9 10 ]…”

Αξιολόγηση Ογκομετρικών Μεθόδων Για Τον Οφθαλμικό Κόγχο

“…Ο οφθαλμικός κόγχος πρόκειται για μία ιδιαίτερη ανατομική και λειτουργική μονάδα του κρανίου με αλλαγές στο όγκο του να εκδηλώνονται με έντονα συμπτώματα (120,200). Υπάρχει ανάγκη για πραγματοποίηση μελετών σε μεγάλη κλίμακα οι οποίες επικεντρώνονται στην σχέση μεταξύ απεικονιστικών και κλινικών σημείων οι οποίες θα βοηθήσουν στη θέσπιση θεραπευτικών αλγορίθμων για την χειρουργική προσέγγιση του κόγχου, η οποία στην παρούσα φάση στηρίζεται κυρίως στην κλινική συμπτωματολογία.…”