Structural gene variants in the porcine mannose-binding lectin 1 (MBL1) gene are associated with low serum MBL-A concentrations

Juul‐Madsen, Helle R.; Kjærup, Rikke M.; Toft, Charlotte; Henryon, Mark; Heegaard, Peter M. H.; Berg, Peer; Dalgaard, Tina Sørensen

doi:10.1007/s00251-011-0512-1

Cited by 13 publications

(20 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Four of these coincided with the homozygous haplotypes A1–A4 previously published by Juul‐Madsen et al . (). Two haplotypes – A2 and A5 – were present among the BC 2 animals.…”

Section: Resultsmentioning

confidence: 97%

“…In the present study, variation was detected at three of four nucleotide positions previously reported to harbour non‐synonymous SNPs (Lillie et al ., ; Juul‐Madsen et al ., ). The SNP A77G corresponds to amino acid 26, which is located in the N‐terminal domain of the protein, and substitutes a glycine for a glutamic acid.…”

Section: Discussionmentioning

confidence: 97%

“…The porcine MBL1 gene and the amplified region (modified from Juul‐Madsen et al ., ). Variation was detected at four SNP s in exons 1 and 2.…”

Section: Methodsmentioning

confidence: 97%

See 2 more Smart Citations

MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic, and Japan

Bergman

Sandholm

Ekdahl

et al. 2012

Int J Immunogenetics

View full text Add to dashboard Cite

The single nucleotide polymorphism (SNP) G949T in the mannose-binding lectin ( MBL ) 1 gene has been associated with low MBL-A concentration in serum and detected at different frequencies in various European pig populations. However, the origin of this SNP is not known. Part of the MBL1 gene was sequenced in 12 wild boar/Large White crossbred pigs from the second backcross (BC 2 ) generation in a family material originating from two wild boar x Large White intercrosses. Also, MBL-A serum concentration was measured in the entire BC 2 generation (n = 45). Furthermore, the genotypes of 68 wild boars from Sweden, Austria, the Czech Republic, and Japan were determined in regard to five previously described SNPs in MBL1 . The T allele of G949T was present among the BC 2 animals. MBL-A serum concentration in the BC 2 animals showed a bimodal distribution, with one-third of the animals at levels between 0.7 and 1.6 μg mL(-1) and the remaining pigs at levels around 13 μg mL(-1) . There was a co-variation between the presence of the T allele and low MBL-A concentration in serum. The genotyping of the wild boars revealed differences between populations. The T allele of G949T was not detected in the Austrian and Japanese samples and is thus unlikely to be an original feature of wild boars. In contrast, it was present at high frequency (0.35) among the Swedish wild boars, probably representing a founder effect. Five MBL1 haplotypes were resolved. Only two of these were present among the Japanese wild boars compared to four in each of the European populations. This difference may reflect differences in selection pressure and population history.

show abstract

“…Four of these coincided with the homozygous haplotypes A1–A4 previously published by Juul‐Madsen et al . (). Two haplotypes – A2 and A5 – were present among the BC 2 animals.…”

Section: Resultsmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic, and Japan

Bergman

Sandholm

Ekdahl

et al. 2012

Int J Immunogenetics

View full text Add to dashboard Cite

show abstract

“…) and pigs (Juul‐Madsen et al . ), with consequences for body mass and disease susceptibility (Lillie et al . ; Bergman ; Bergman et al .…”

Section: Discussionmentioning

confidence: 99%

“…) and pigs (Juul‐Madsen et al . ). Here, we analysed the variability of its putative promoter region which is associated with low body weight and disease susceptibility in domestic ungulates (Schou et al .…”

Section: Methodsmentioning

confidence: 97%

Immunogenetic heterogeneity in a widespread ungulate: the European roe deer (Capreolus capreolus)

et al. 2015

View full text Add to dashboard Cite

Understanding how immune genetic variation is shaped by selective and neutral processes in wild populations is of prime importance in both evolutionary biology and epidemiology. The European roe deer (Capreolus capreolus) has considerably expanded its distribution range these last decades, notably by colonizing agricultural landscapes. This range shift is likely to have led to bottlenecks and increased roe deer exposure to a new range of pathogens that until recently predominantly infected humans and domestic fauna. We therefore investigated the historical and contemporary forces that have shaped variability in a panel of genes involved in innate and acquired immunity in roe deer, including Mhc-Drb and genes encoding cytokines or toll-like receptors (TLRs). Together, our results suggest that genetic drift is the main contemporary evolutionary force shaping immunogenetic variation within populations. However, in contrast to the classical view, we found that some innate immune genes involved in micropathogen recognition (e.g. Tlrs) continue to evolve dynamically in roe deer in response to pathogen-mediated positive selection. Most studied Tlrs (Tlr2, Tlr4 and Tlr5) had similarly high levels of amino acid diversity in the three studied populations including one recently established in southwestern France that showed a clear signature of genetic bottleneck. Tlr2 implicated in the recognition of Gram-positive bacteria in domestic ungulates, showed strong evidence of balancing selection. The high immunogenetic variation revealed here implies that roe deer are able to cope with a wide spectrum of pathogens and to respond rapidly to emerging infectious diseases.

show abstract

Bovine Collectins: Role in Health and Disease

Tsolaki

Kishore

2021

The Collectin Protein Family and Its Multiple Biological Activities

View full text Add to dashboard Cite

Mammalian collectins play key roles in innate immunity, health and disease. These have been well studied in humans and other mammalian species, but much has still to be learned about the bovine collectins and the role they may play in the health and disease in cattle which have significant economic implications to the agricultural and food industries. This chapter focuses on the bovine collectins, which are important innate immune molecules and play a key role in immunoregulation and protection against pathogens. Like other mammalian collectins, they all have a related structure comprised of an N-terminal triple-helical collagen-like region and a ligand binding C-terminal C-type lectin domain. The bovine collectins are able to recognise and bind to complex glycoconjugates, particularly on the surface of microbes, neutralising infection, enhancing clearance by phagocytes and modulating immune response. Here, we will review the bovine collectins, surfactant proteins A (SP-A) and D (SP-D), mannose binding lectins (MBL-A and MBL-C), conglutinin (CGN), collectin 43 (CL-43) and collectin 46 (CL-46), and their role in bovine immunity and disease. We will particularly focus on the structural, functional and anti-microbial roles of these collectins with an additional focus on genetic polymorphisms in their genes and predisposition to infectious diseases in the bovine host. In the absence of specific data on the bovine host, findings from studies with other mammalian collectins will be discussed with respect to bovine health and disease.

show abstract

Structural gene variants in the porcine mannose-binding lectin 1 (MBL1) gene are associated with low serum MBL-A concentrations

Cited by 13 publications

References 23 publications

MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic, and Japan

MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic, and Japan

Immunogenetic heterogeneity in a widespread ungulate: the European roe deer (Capreolus capreolus)

Bovine Collectins: Role in Health and Disease

Contact Info

Product

Resources

About