2023
DOI: 10.1371/journal.pcbi.1011398
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Structural identifiability of biomolecular controller motifs with and without flow measurements as model output

Eivind S. Haus,
Tormod Drengstig,
Kristian Thorsen

Abstract: Controller motifs are simple biomolecular reaction networks with negative feedback. They can explain how regulatory function is achieved and are often used as building blocks in mathematical models of biological systems. In this paper we perform an extensive investigation into structural identifiability of controller motifs, specifically the so–called basic and antithetic controller motifs. Structural identifiability analysis is a useful tool in the creation and evaluation of mathematical models: it can be use… Show more

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