Structural, immunological, and antioxidant studies of β-glucan from edible mushroom Entoloma lividoalbum

Maity, Prasenjit; Sen, Ipsita K.; Maji, Praloy K.; Paloi, Soumitra; Devi, K. Sanjana P.; Acharya, Krishnendu; Maiti, Tapas K.; Islam, Syed S.

doi:10.1016/j.carbpol.2015.01.051

Cited by 63 publications

(29 citation statements)

References 36 publications

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“…As shown in Fig.7C, the scavenging activity on superoxide anion of the EPS, 44.86 ± 0.30% at the dose of mg/ml, was lower than that of Vc (99.14 ± 0.24%). Maity et al [54] reported 56.58% of superoxide anion scavenging activity for the glucan extracted from edible mushroom at 1 mg/ml. Liu et al [55] indicated that the molecular weight of dextran markedly influenced its superoxide anion scavenging activity; two glucans obtained from Ganoderma lucidum mushroom with 5.2 kDa annd 15 kDa had 80% and 50% of the scavenging activity, respectively.…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

Characterization and Antioxidant Activity of the Exopolysaccharide Produced by Bacillus amyloliquefaciens GSBa-1

Zhao¹,

Zhang²,

Jiang³

et al. 2018

Journal of Microbiology and Biotechnology

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The exopolysaccharide (EPS) produced by Bacillus amyloliquefaciens GSBa-1 was isolated and purified by ethanol precipitation, DEAE-cellulose and Sepharose CL-6B chromatography. The molecular weight of the purified EPS was determined to be 54 kDa. Monosaccharide analysis showed that the EPS was composed of predominantly glucose, and it was further confirmed by NMR spectroscopy to be α-glucan consisted of a trisaccharide repeating unit with possible presence of two α-(1→3) and one α-(1→6) glucosidic linkages. Microstructural analysis showed that the EPS appeared as ellipsoid or globose with smooth surface. The EPS had a degration temperature at 240℃. Furthermore, the EPS had strong DPPH and hydroxyl radical scavenging activities, and moderate scavenging activities on superoxidant anion and metal ion chelating activity. This is the first characterization of a glucan produced by B. amyloliquefaciens with strong antioxidant activity. The results of this study suggested the potential of the EPS from B. amyloliquefaciens GSBa-1 to serve as a natural antioxidant for application in functional products.

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Section: Antioxidant Propertiesmentioning

confidence: 99%

Characterization and Antioxidant Activity of the Exopolysaccharide Produced by Bacillus amyloliquefaciens GSBa-1

Zhao¹,

Zhang²,

Jiang³

et al. 2018

Journal of Microbiology and Biotechnology

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“…These polymers have been undergoing investigations as to their biological, physiological and pharmacological potentials both in vitro and in vivo. Data already point toward their possible use in treating different types of cancer due to their antitumor [8], anti-proliferative [9] and immune response modulating [10,11] potential. In addition, the pharmacological potential of β-glucans may also be availed in other areas since they can behave as anti-nociceptive [12] and antioxidant [13] agents.…”

Section: Introductionmentioning

confidence: 99%

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Soeiro

Melo

Alves

et al. 2016

IJMS

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Dextrans (α-d-glucans) extracted from Leuconostoc mesenteroides, with molecular weights (MW) of 10 (D10), 40 (D40) and 147 (D147) kDa, were evaluated as antioxidant, anticoagulant and immunomodulatory drugs for the first time. None presented anticoagulant activity. As for the antioxidant and immunomodulatory tests, a specific test showed an increase in the dextran activity that was proportional to the increase in molecular weight. In a different assay, however, activity decreased or showed no correlation to the MW. As an example, the reducing power assay showed that D147 was twice as potent as other dextrans. On the other hand, all three samples showed similar activity (50%) when it came to scavenging the OH radical, whereas only the D10 sample showed sharp activity (50%) when it came to scavenging the superoxide ion. D40 was the single dextran that presented with immunomodulatory features since it stimulated the proliferation (~50%) of murine macrophages (RAW 264.7) and decreased the release of nitric oxide (~40%) by the cells, both in the absence and presence of lipopolysaccharides (LPS). In addition, D40 showed a greater scavenging activity (50%) for the hydrogen peroxide, which caused it to also be the more potent dextran when it came to inhibiting lipid peroxidation (70%). These points toward dextrans with a 40 kDa weight as being ideal for antioxidant and immunomodulatory use. However, future studies with the D40 and other similarly 40 kDa dextrans are underway to confirm this hypothesis.

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“…28 For monosaccharide analysis, the PS (3 mg) was hydrolyzed with 2 M CF 3 COOH (2 mL) in a round-bottom flask at 100 C for 18 h in a water bath and the analysis was carried out as described in earlier publications. 20,35,36 Methylation experiment was carried out by the method described previously.…”

Section: General Methodsmentioning

confidence: 99%

Heteroglycan of an edible mushroom Termitomyces clypeatus: structure elucidation and antioxidant properties

Pattanayak

Samanta

Maity

et al. 2015

Carbohydrate Research

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Structural, immunological, and antioxidant studies of β-glucan from edible mushroom Entoloma lividoalbum

Cited by 63 publications

References 36 publications

Characterization and Antioxidant Activity of the Exopolysaccharide Produced by Bacillus amyloliquefaciens GSBa-1

Characterization and Antioxidant Activity of the Exopolysaccharide Produced by Bacillus amyloliquefaciens GSBa-1

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Heteroglycan of an edible mushroom Termitomyces clypeatus: structure elucidation and antioxidant properties

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