Structural Insights into Seeding Mechanisms of hIAPP Fibril Formation
Saba Suladze,
Christian Sustay Martinez,
Diana C. Rodriguez Camargo
et al.
Abstract:The deposition of islet amyloid polypeptide (hIAPP) fibrils
is
a hallmark of β-cell death in type II diabetes. In this study,
we employ state-of-the-art MAS solid-state spectroscopy to investigate
the previously elusive N-terminal region of hIAPP fibrils, uncovering
both rigidity and heterogeneity. Comparative analysis between wild-type
hIAPP and a disulfide-deficient variant (hIAPPC2S,C7S)
unveils shared fibril core structures yet strikingly distinct dynamics
in the N-terminus. Specifically, the variant fibri… Show more
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