Structural inspection for novel Pd(II), VO(II), Zn(II) and Cr(III)- azomethine metal chelates: DNA interaction, biological screening and theoretical treatments

Aljohani, Faizah S.; Abu‐Dief, Ahmed M.; El‐Khatib, Rafat M.; AL-Abdulkarim, Hessah A.; Alharbi, Arwa; Mahran, Asmaa; Khalifa, Mohamed E.; El‐Metwaly, Nashwa M.

doi:10.1016/j.molstruc.2021.131139

Cited by 74 publications

(26 citation statements)

References 67 publications

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“…In methanol, the violet solution (4 × 10 −3 % w/v) stayed kept at 10°C in the darkness. [ 33 ] In methanol, concentrations of the complexes were produced at 1280, 640, 320, 160, 80, 40, 20, 10, and 0.0 μg ml −1 . Forty milliliters of individual component was added to DPPH (3 ml), beside the intensity was measured spectrophotometrically.…”

Section: Methodsmentioning

confidence: 99%

“…The proportion of radical reserve (PI) was calculated using Equation :

PI goodbreak= ([], ((), A_{control} goodbreak- A_{complex}) / A_{control}) goodbreak\times 100 %

where A complex = DPPH absorbance + chelate at t = 16 min, beside A control = DPPH radical absorbance. [ 33 ]…”

Section: Methodsmentioning

confidence: 99%

“…where A complex = DPPH absorbance + chelate at t = 16 min, beside A control = DPPH radical absorbance. [33]…”

Section: Antioxidant Properties In Vitromentioning

confidence: 99%

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Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

El‐Bindary

El-Bindary

2022

Applied Organom Chemis

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A chain of metal(II) chelates that M = Co2+, Ni2+, and Cu2+ have been produced from 2‐(4‐sulfadiazine)hydrazono dimedone (HL) and characterized on analyses of elemental, Fourier‐transform infrared (FTIR) spectra, electronic, susceptibility to magnetic fields, and molar conductance. The chelates are nonelectrolytes, according to measurements of conductance. Spectroscopy methods and additional analytical measurements detect pseudo octahedral shape of Co2+ and Ni2+ chelates, but square planar structure for Cu2+ chelate. The ligand (HL) acts as a monobasic bidentate ligand by coordinating via oxygen atom of the carbonyl (C═O) group and the nitrogen atom of the hydrazone moiety (NH) with deprotonation. The enhanced, bond angles, bond lengths, and quantum chemical factors were used to determine the ligand and its complexes. Absorption spectra method and measurements of viscosity were used to investigate DNA linking activity. In the viability experiment of vinblastine and colchicine, the findings of synthesized compounds against the human cancer cell lines MCF‐7 and HepG‐2 were reported in contrast to positive controls. The antioxidant function of chelates is resolute by means of the free radical‐scavenging analyze (DPPH). As a final point, the antimicrobial effects of the chelates were studied utilizing the diffusion disc technique on fungal (Candida albicans), gram‐positive (Staphylococcus aureus), and gram‐negative (Escherichia coli) bacteria.

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Section: Methodsmentioning

confidence: 99%

“…The proportion of radical reserve (PI) was calculated using Equation :

PI goodbreak= ([], ((), A_{control} goodbreak- A_{complex}) / A_{control}) goodbreak\times 100 %

where A complex = DPPH absorbance + chelate at t = 16 min, beside A control = DPPH radical absorbance. [ 33 ]…”

Section: Methodsmentioning

confidence: 99%

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Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

El‐Bindary

El-Bindary

2022

Applied Organom Chemis

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“…After overnight incubation, cells were treated with the test compounds. After incubation for 3 days at 37 °C, the formazan-based 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 H -tetrazolium (MTS) cell viability assay (CellTiter 96 ® AQueous One Solution Cell Proliferation Assay, Promega) was performed to assess cell viability, and the spectrophotometric data were used to calculate the IC 50 values [ 61 – 65 ].…”

Section: Methodsmentioning

confidence: 99%

Anthranilamides with quinoline and β-carboline scaffolds: design, synthesis, and biological activity

et al. 2022

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Graphical abstract In the present study, we report the design and synthesis of novel amide-type hybrid molecules based on anthranilic acid and quinoline or β-carboline heterocyclic scaffolds. Three types of biological screenings were performed: (i) in vitro antiproliferative screening against a panel of solid tumor and leukemia cell lines, (ii) antiviral screening against several RNA viruses, and (iii) anti-quorum sensing screening using gram-negative Chromobacterium violaceum as the reporter strain. Antiproliferative screening revealed a high activity of several compounds. Anthranilamides 12 and 13 with chloroquine core and halogenated anthranilic acid were the most active agents toward diverse cancer cell lines such as glioblastoma, pancreatic adenocarcinoma, colorectal carcinoma, lung carcinoma, acute lymphoblastic, acute myeloid, chronic myeloid leukemia, and non-Hodgkin lymphoma, but also against noncancerous cell lines. Boc-protected analogs 2 and 3 showed moderate activities against the tested cancer cells without toxic effects against noncancerous cells. A nonhalogenated quinoline derivative 10 with N -benzylanthranilic acid residue was equally active as 12 and 13 and selective toward tumor cells. Chloroquine and quinoline anthranilamides 10 – 13 exerted pronounced antiviral effect against human coronaviruses 229E and OC43, whereas 12 and 13 against coronavirus OC43 (EC 50 values in low micromolar range; selectivity indices from 4.6 to > 10.4). Anthranilamides 14 and 16 with PQ core inhibited HIV-1 with EC 50 values of 9.3 and 14.1 µM, respectively. Compound 13 displayed significant anti-quorum/biofilm effect against the quorum sensing reporter strain (IC 50 of 3.7 μM) with no apparent bactericidal effect. Supplementary Information The online version contains supplementary material available at 10.1007/s11030-021-10347-8.

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“… 8 Besides, the Pd( ii ) complex of 1-quinolin-8-yliminomethyl-naphthalen-2-ol exhibited antibacterial activity against S. marcescent , E. coli , and M. luteus microbes with MIC of 2.25–3.75 μM. 10 …”

Section: Introductionmentioning

confidence: 98%

Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans

Mansour

2021

RSC Adv.

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Structural inspection for novel Pd(II), VO(II), Zn(II) and Cr(III)- azomethine metal chelates: DNA interaction, biological screening and theoretical treatments

Cited by 74 publications

References 67 publications

Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

Anthranilamides with quinoline and β-carboline scaffolds: design, synthesis, and biological activity

Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans

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