Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review

Arora, Mohit; Choudhary, Shalki; Singh, Pankaj Kumar; Sapra, Bharti; Silakari, Om

doi:10.1016/j.lfs.2020.117631

Cited by 60 publications

(30 citation statements)

References 72 publications

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“…42 Selective inhibitors of COX-2 are known to increase the risk of cardiotoxicity. 43 Valdecoxib is a selective COX-2 inhibitor with less effect on platelet aggregation and displays bridged gastrointestinal complications. 44,45 Arachidonic acid is a natural substrate that is metabolized to both pro-inflammatory and anti-inflammatory eicosanoids during and after the inflammatory response, respectively.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Mondal

Quispe

Sarkar

et al. 2021

Natural Product Communications

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The objective of our present study is to scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of 100, 200, and 400 mg/kg body weight. Twenty chemical compounds, which were isolated from the leaves essential oil of E. camaldulensis, were docked using AutodockVina against cyclooxygenase 2, tumor necrosis factor-α, and interleukin-1β convertase to elucidate the analgesic and anti-inflammatory activity. The essential oil of E. camaldulensis exhibited noteworthy analgesic activities in the writhing test. In the tail immersion and hot-plate test, the essential oil significantly extended the latency period. The number of licks in the formalin-induced paw licking test was markedly reduced following essential oil administration. In addition, E. camaldulensis essential oil revealed notable anti-inflammatory responses in carrageenan-induced paw edema, xylene induced ear edema and cotton pellet induced granuloma methods. Among 20 compounds, 5 ( cis-sabinol, globulol, α-eudesmol, β-eudesmol, and γ-eudesmol) showed better binding for cyclooxygenase-2 while β-eudesmol exhibited higher affinity for TNFα than that of TNF-alpha-IN-1 and standard drug. In the case of interleukin 1β convertase, maximum affinity was shown by α-eudesmol than the synthetic drug belnacasan. Chemical components of the essential oil interacted with diverse amino acid residues which were similar to the natural substrate and standard drugs. In conclusion, E. camaldulensis essential oil can be an effective source of analgesic and anti-inflammatory treatment and additional modification and docking studies will be required to justify the efficiency of globulol, α-eudesmol, β-eudesmol, and γ-eudesmol.

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Section: Discussionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Mondal

Quispe

Sarkar

et al. 2021

Natural Product Communications

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“…It is because of possible detrimental impacts on the heart and possible fatal consequences that every drug during pre-clinical development must be tested for cardiotoxicity [ 147 , 195 ]. Cardiotoxicity remains a major decision factor for success or failure in clinical drug development and successful marketing (e.g., in the case of the COX-2 inhibitor rofecoxib for arthritis [ 196 , 197 , 198 , 199 , 200 ]).…”

Section: Myofilaments and Ca 2+ Responsivenessmentioning

confidence: 99%

Calcium and Heart Failure: How Did We Get Here and Where Are We Going?

Siri‐Angkul

Dadfar

Jaleel

et al. 2021

IJMS

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The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 seconds from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures for end-stage heart failure. This exploration has resulted in many failed clinical trials testing novel classes of pharmaceutical drugs and even gene therapy. As a result, along the way, there have been paradigm shifts toward and away from differing therapeutic approaches. The continued prevalence of death from heart failure, however, clearly demonstrates that the heart is not simply a pump and instead forces us to consider the complexity of simplicity in the pathophysiology of heart failure and reinforces the need to discover new therapeutic approaches.

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“…This extra pocket fits the butterfly shaped COX‐2 inhibitors absolutely into the V‐shaped binding pocket. However, this butterfly shape is accountable for the cardiotoxicity of selective COX‐2 inhibitors [12] . Selective COX‐2 inhibitors reduce vasodilatory prostaglandin synthesis leading to renal ischemia by promoting sodium retention and causing altered systolic and diastolic blood pressure, which in due course leads to cardiac problems [13] .…”

Section: Introductionmentioning

confidence: 99%

Structural Insights into Pyrazoles as Agents against Anti‐inflammatory and Related Disorders

et al. 2022

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Pyrazole moiety is considered as the most important therapeutic agent for the treatment of inflammation and inflammation associated cancers. Celecoxib, Ramifenazone, Rimonabant and Lonazolac are some of the commercially available pyrazole moieties which are potent COX‐2 inhibitors and also acts in inhibiting various cancers. Recently there are numerous reviews on the biological significance of pyrazole derivatives. However, this review discusses pyrazole derivatives possessing anti‐inflammatory and anticancer activity (COX inhibition) and also illustrates the recent updates on pyrazole research emphasizing on the medicinal chemistry aspects such as the key structural fragments required for the biological activity. There are series of pyrazoles like di‐substituted, tri‐substituted, tetra‐substituted pyrazoles, pyrazole hydrazones, pyrazoles bearing various other heterocycles, bicyclic fused pyrazoles, tricyclic fused pyrazoles, and miscellaneous class of pyrazoles. All these pyrazoles are being researched as COX inhibitors, anti‐inflammatory and against related disorders like cancer.

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Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review

Cited by 60 publications

References 72 publications

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Calcium and Heart Failure: How Did We Get Here and Where Are We Going?

Structural Insights into Pyrazoles as Agents against Anti‐inflammatory and Related Disorders

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