“…Based on this study alone, it cannot be concluded that fetal brain TH measurements do not provide added value to serum TH measurements in the CTA with small group size. Recent research studies using environmental contaminants on TH disruption were conducted using varying numbers of animals, e.g., less than or about 10 animals per dose ( Ramhøj et al, 2018 , Ramhøj et al, 2022 , Gilbert et al, 2021 , Gilbert et al, 2022 , Gilbert et al, 2023 ), 15–16 animals per dose ( Ramhøj et al, 2020 ), or two balanced blocks and comprised three treatment groups of 22 dams each ( Ramhøj et al, 2022 ). Although these are informative, they are not sufficient to draw conclusions because brain TH concentrations were not measured in all cases.…”