Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis

Verstraete, Esther; Veldink, Jan H.; Hendrikse, Jeroen; Schelhaas, Helenius J.; Heuvel, Martijn P. van den; Berg, Leonard H. van den

doi:10.1136/jnnp-2011-300909

Cited by 134 publications

(154 citation statements)

References 45 publications

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“…The subcortical hypointense line corresponding to U-fibers appears smooth, and the gray-white junction, poorly demarcated ( Fig 1A, -B). When the M1 anatomy differed from such configurations, and namely the M1 deeper layers were particularly thin 23,29 and/or hypointense 9,30 ( Fig 1D, -E), images were judged as belonging to patients with ALS. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy in distinguishing patients and HS were calculated for each reader.…”

Section: Image Analysismentioning

confidence: 99%

High-Resolution 7T MR Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis

Cosottini¹,

Donatelli

Costagli³

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis is a progressive motor neuron disorder that involves degeneration of both upper and lower motor neurons. In patients with amyotrophic lateral sclerosis, pathologic studies and ex vivo high-resolution MR imaging at ultra-high field strength revealed the co-localization of iron and activated microglia distributed in the deep layers of the primary motor cortex. The aims of the study were to measure the cortical thickness and evaluate the distribution of iron-related signal changes in the primary motor cortex of patients with amyotrophic lateral sclerosis as possible in vivo biomarkers of upper motor neuron impairment.

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Section: Image Analysismentioning

confidence: 99%

High-Resolution 7T MR Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis

Cosottini¹,

Donatelli

Costagli³

et al. 2015

AJNR Am J Neuroradiol

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“…Compared with VBM studies, SBM studies of patients with ALS uniformly report reduced cortical thickness in primary motor regions [28][29][30][31]. While SBM provides measures of cortical surface area and cortical volume, it has been demonstrated that cortical thickness is the key metric to detect changes in ALS [30].…”

Section: Volumetric Imagingmentioning

confidence: 99%

“…While SBM provides measures of cortical surface area and cortical volume, it has been demonstrated that cortical thickness is the key metric to detect changes in ALS [30]. Cortical thinning has been shown to be a consistent alteration that is specific to upper motor neuron degeneration in ALS.…”

Section: Volumetric Imagingmentioning

confidence: 99%

“…However, significant challenges remain for analyzing the imaging data and establishing sufficient diagnostic accuracy. Several phase 2 studies have evaluated the diagnostic accuracy using single neuroimaging modalities, such as DTI and cortical thickness, with encouraging results, although clinical utility is currently limited [28,30,32,58,[97][98][99][100][101]. Using different statistical approaches, two meta-analyses evaluated several DTI studies and found that a single imaging metric results in marginal diagnostic accuracy measures (Fig.…”

Section: Challenges For Analysesmentioning

confidence: 99%

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Neuroimaging as a New Diagnostic Modality in Amyotrophic Lateral Sclerosis

Verstraete

Foerster

2015

Neurotherapeutics

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Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of upper and lower motor neurons, with variable involvement of extramotor brain regions. Currently, there are no established objective markers of upper motor neuron and extramotor involvement in ALS. Here, we review the potential diagnostic value of advanced neuroimaging techniques that are increasingly being used to study the brain in ALS. First, we discuss the role of different imaging modalities in our increasing understanding of ALS pathogenesis, and their potential to contribute to objective upper motor neuron biomarkers for the disease. Second, we discuss the challenges to be overcome and the required phases of diagnostic test development to translate imaging technology to clinical care. We also present examples of multidimensional imaging approaches to achieve high levels of diagnostic accuracy. Last, we address the role of neuroimaging in clinical therapeutic trials. Advanced neuroimaging techniques will continue to develop and offer significant opportunities to facilitate the development of new effective treatments for ALS.

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“…Morphological changes in amyotrophic lateral sclerosis (ALS) patients by structural MRI analysis 42,43 as well as sensorimotor functional connectivity changes in ALS patients 21 have been reported recently. In this work, as an example for application of the analysis methods WBSS and TFAS, twenty ALS patients were investigated by multiparametric MRI.…”

Section: Dti In Neurodegeneration (Motor Neuron Diseases)mentioning

confidence: 99%

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Müller

Kassubek

2013

JoVE

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Diffusion tensor imaging (DTI) techniques provide information on the microstructural processes of the cerebral white matter (WM) in vivo. The present applications are designed to investigate differences of WM involvement patterns in different brain diseases, especially neurodegenerative disorders, by use of different DTI analyses in comparison with matched controls.DTI data analysis is performed in a variate fashion, i.e. voxelwise comparison of regional diffusion direction-based metrics such as fractional anisotropy (FA), together with fiber tracking (FT) accompanied by tractwise fractional anisotropy statistics (TFAS) at the group level in order to identify differences in FA along WM structures, aiming at the definition of regional patterns of WM alterations at the group level. Transformation into a stereotaxic standard space is a prerequisite for group studies and requires thorough data processing to preserve directional interdependencies. The present applications show optimized technical approaches for this preservation of quantitative and directional information during spatial normalization in data analyses at the group level. On this basis, FT techniques can be applied to group averaged data in order to quantify metrics information as defined by FT. Additionally, application of DTI methods, i.e. differences in FA-maps after stereotaxic alignment, in a longitudinal analysis at an individual subject basis reveal information about the progression of neurological disorders. Further quality improvement of DTI based results can be obtained during preprocessing by application of a controlled elimination of gradient directions with high noise levels.In summary, DTI is used to define a distinct WM pathoanatomy of different brain diseases by the combination of whole brain-based and tractbased DTI analysis. Video LinkThe video component of this article can be found at

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Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis

Abstract: Cortical thinning of the primary motor cortex might be a diagnostic marker for upper motor neuron degeneration in ALS. Relative thinning in temporal regions was associated with a rapidly progressive disease course.

Cited by 134 publications

References 45 publications

High-Resolution 7T MR Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis

High-Resolution 7T MR Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis

Neuroimaging as a New Diagnostic Modality in Amyotrophic Lateral Sclerosis

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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