Structural myocardial alterations in diabetes and hypertension: the role of galectin-3

Seferović, Jelena P.; Lalić, Nebojša; Floridi, Federico; Tešić, Milorad; Seferović, Petar; Lalić, Katarina; Jotić, Aleksandra; Jovičić, Snežana; Čolak, Emina; Salerno, Gerardo; Cardelli, Patrizia; Somma, Salvatore Di

doi:10.1515/cclm-2014-0265

Cited by 20 publications

(17 citation statements)

References 6 publications

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“…In another study carried out with diabetic and hypertensive patients, galectin levels were detected to be higher among hypertensive patients compared with normotensives and were determined to be associated with myocardial fibrosis, which was evaluated with late gadolinium enhancement [34]. Similarly, in our study, galectin-3 levels were found to be strongly correlated with LMVI among hypertensive patients as well.…”

Section: Discussionsupporting

confidence: 81%

Assessment of relationship between galectin-3 and ambulatory ECG-based microvolt T-wave alternans in sustained systolic-diastolic hypertension patients

Püşüroğlu

Akgül²,

Ertürk³

et al. 2016

Blood Pressure Monitoring

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Section: Discussionsupporting

confidence: 81%

Assessment of relationship between galectin-3 and ambulatory ECG-based microvolt T-wave alternans in sustained systolic-diastolic hypertension patients

Püşüroğlu

Akgül²,

Ertürk³

et al. 2016

Blood Pressure Monitoring

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“…In this study, higher levels of Gal-3 are associated with the development of type 2 DM. The obtained results substantiate the study of Seferovic et al, [28] which describes elevated levels of Gal-3 in patients with type 2 DM that were strongly correlated with HbA1c levels. Yilmaz et al [29] showed that Gal-3 may be an independent predictor of type 2 DM in general.…”

Section: [27]supporting

confidence: 91%

Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes

Bobronnikova¹

2017

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How to cite this article: Bobronnikova L. Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes. Vessel Plus 2017;1:61-7. Aim:To determine the impact of galectin-3 levels on the progression of metabolic disorders and structural-functional changes in the myocardium and blood vessels in patients with concomitant systemic arterial hypertension (AH) and type 2 diabetes mellitus (type 2 DM). Methods: Ninety-five patients with hypertension stage II grade 2 (53 males and 42 females) were examined. The patients were separated: group 1 (n = 32) patients with AH, without carbohydrate metabolism disorders; group 2 (n = 30) patients with AH and pre-diabetes; group 3 (n = 33) concomitant AH and type 2 DM. Carbohydrate metabolism, insulin resistance parameters and galectin-3 levels were measured. Echocardiography was performed to determine the structural-functional condition of the heart. Estimation of the intima-media complex thickness of the common carotid artery was performed by duplex ultrasound scanning. Results: Hypertrophy of the left ventricular myocardium is most evident in patients with AH and type 2 DM compared with groups 1 and 2, and the control group (P < 0.05). The levels of galectin-3 in the group with concomitant hypertension and type 2 DM were higher than in groups 1 and 2, and the control group (P < 0.05). A positive correlation was revealed between the level of galectin-3, indices of insulin resistance, and structural-functional cardiac and vessel remodeling. Conclusion: Galectin-3 levels in serum are significantly linked with indices of insulin resistance and cardiovascular remodeling. Key words:Arterial hypertension, type 2 diabetes mellitus, insulin resistance, cardiovascular remodeling, galectin-3 ABSTRACTArticle history:

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“…In clinical studies, circulating galectin-3 was higher in type 2 DM patients [71][72][73][74] and thought to be a risk factor for vascular complications, such as heart failure, nephropathy, peripheral artery disease, and other vascular complications. 71 Patients with galectin-3 level 25 ng/mL exhibited a 11.4-fold higher risk of microvascular complications (retinopathy and/or nephropathy) and a 8.5-fold increased risk of macrovascular complications (myocardial infraction, angina pectoris, cerebrovascular event, and peripheral artery disease) compared to patients with galectin-3 level 10 ng/mL.…”

Section: Galectin-3 In Metabolic Disease Pathogenesismentioning

confidence: 99%

Galectin-3 and Inflammation

Wan

Liu

2016

Glycobiology Insights

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ABSTRACT:Galectins are a family of β-galactoside-binding proteins that share a consensus sequence in the carbohydrate recognition domain (CRD). Galectin-3 is the most widely studied family member and can be found in the cellular cytoplasm and nucleus, as well as extracellularly in various tissues. The 30-kDa molecule contains an N-terminal proline-rich domain that is important for its oligomerization and a C-terminal CRD for carbohydrate-binding activity. Many studies have shown that galectin-3 may regulate inflammation through a variety of mechanisms. Endogenous galectin-3 has been shown to be involved in the pathogenesis of various diseases, such as fibrosis in the lung, liver, and heart, diabetes mellitus, coronary artery disease, and allergic diseases. In this review, we briefly discuss the pro-or anti-inflammatory roles, as well as potential clinical implications of galectin-3 in these disorders.

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Structural myocardial alterations in diabetes and hypertension: the role of galectin-3

Abstract: This study revealed that levels of galectin-3 were higher in patients with both T2D and HT, and correlated with LV mass, indicating the potential role of this biomarker for early detection of myocardial structural and functional alterations.

Cited by 20 publications

References 6 publications

Assessment of relationship between galectin-3 and ambulatory ECG-based microvolt T-wave alternans in sustained systolic-diastolic hypertension patients

Assessment of relationship between galectin-3 and ambulatory ECG-based microvolt T-wave alternans in sustained systolic-diastolic hypertension patients

Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes

Galectin-3 and Inflammation

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