Structural observations of time dependent oscillatory behavior of CuIICl2 solutions measured via extended X-ray absorption fine structure

Morré, D. James; Heald, Steve M.; Coleman, John; Orczyk, John J.; Jiang, Ziying

doi:10.1016/j.jinorgbio.2006.12.010

Cited by 7 publications

(11 citation statements)

References 28 publications

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“…The hypothesis under investigation is that oscillations in redox potential and oxidation of NADH of hydrated Cu II both in solution and associated with protein [1][2][3][4] were inherent in the properties of the associated water. To test the hypothesis, EXAFS measurements previously made on Cu II Cl 2 solution [4] were extended to double distilled water at 9302 eV with continuous measurements (absorbance recordings every 10 s).…”

Section: Resultsmentioning

confidence: 99%

“…The X-ray absorbance studies were conducted at the Pacific Northwest consortium collaborative access team (PNC-CAT) at the advance photon source (APS) of Argonne National Laboratories as described [4]. The experiments were at 25°C and at intrinsic pH around 4.2.…”

Section: Methodsmentioning

confidence: 99%

“…1. Moving average of EXAFS measurements recorded at intervals of 10 s at a constant k (Å À1 ) of 9.3 as described [4]. An oscillatory pattern was observed with a recurring pattern of 5 maxima (arrows).…”

Section: Introductionmentioning

confidence: 97%

“…In a previous report [4], a possible underlying pattern of distortion in the four equatorial oxygens of the Cu II aqua ion at a close distance relative to the two axial oxygen atoms at a longer distance was sought from extended X-ray absorption fine structure (EXAFS) studies that might correlate with changes in redox potential sufficient to catalyze NADH oxidation in solution. The findings were consistent with changes in the coordinated water molecules of the Cu II aqua ion possibly related to a metastable equilibrium condition in the ratio of ortho to para nuclear spin orientation of the water-associated hydrogen atoms.…”

Section: Introductionmentioning

confidence: 99%

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Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Morré

Orczyk

Hignite

et al. 2008

Journal of Inorganic Biochemistry

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Morré

Orczyk

Hignite

et al. 2008

Journal of Inorganic Biochemistry

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“…Thus, the copper bound to the ENOX protein, as a Cu II hexahydrate, emerged as the driver of the protein oscillations, a conclusion supported by Extended X-ray Absorption Fine Structure Spectroscopy (EXAFS) measurements using the Advanced Photon Source of the Argonne National Laboratories [12]. Ultimately, similar oscillations in both redox potential and in NADH oxidation were observed in pure water with a period length of about 18 min (24 min for D2O) and also confirmed by EXAFS [13].…”

Section: Time-keeping Enox Proteinsmentioning

confidence: 95%

Synchronous Oscillations Intrinsic to Water: Applications to Cellular Time Keeping and Water Treatment

Morré¹,

Morré²

2015

Water

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Abstract:A homodimeric, growth-related and time-keeping hydroquinone oxidase (ENOX1) of the eukaryotic cell surface capable of oxidizing intracellular NADH exhibits properties of the ultradian driver of the biological 24 h circadian clock by exhibiting a complex 2 + 3 set of oscillations of copper salts and appear to derive from periodic variations in the ratio of ortho and para nuclear spins of the paired hydrogen atoms of the elongated octahedral structure of the ENOX1 protein bound copper II hexahydrates. A corollary of these observations is that the ortho/para oscillations must occur in a highly synchronized matter. Our findings suggest that water molecules communicate with each other via very low frequency electromagnetic fields and that these fields also appear to be generated by the energetics of the synchronous ortho to para interconversions of the nuclear spin pairs of the water hydrogens. Further evidence for energy absorbed and emitted by water and correlated with ortho/para oscillations of ortho/para spin pairs of water hydrogens is indicated from the auto-oscillations in water luminescence. The emissions oscillate with period lengths of 18.8 min that agree with our previously found period of oscillation of about 18 min for pure water, reflective of ortho to para spin isomers based on measurements of redox potential. The period length of pure water (increased by about 25% in D2O) and varies depending on the dominant cation present (copper salts in solution are unique in that the period length is exactly 24 min). Synchrony is maintained through generation of and response to LFEMF generated by the ortho-para spin pairs. Changes in redox potential sufficient to catalyze NADH oxidation were used to monitor synchronous water oscillations that appear to extend indefinitely over great distances in contiguous bodies of OPEN ACCESSWater 2015, 7 2083 either still or flowing water. Adjacent out-of-phase water samples contained in thin plastic cuvettes auto-synchronize in a matter of seconds when placed side by side. Potential applications from water treatment along with opportunity related to human health are anticipated to derive from a better understanding of how water synchrony is generated and maintained, and to be aided by methodological advances in measurement and analysis.Keywords: oscillations intrinsic to water; oscillations in ortho-para nuclear spins of paired hydrogens of water; time-keeping; water coherence; water treatment; electrodermal sensing

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ENOX Proteins, Copper Hexahydrate-Based Ultradian Oscillators of the Cells’ Biological Clock

Morré

2008

Ultradian Rhythms From Molecules to Mind

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Structural observations of time dependent oscillatory behavior of CuIICl2 solutions measured via extended X-ray absorption fine structure

Cited by 7 publications

References 28 publications

Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Synchronous Oscillations Intrinsic to Water: Applications to Cellular Time Keeping and Water Treatment

ENOX Proteins, Copper Hexahydrate-Based Ultradian Oscillators of the Cells’ Biological Clock

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