Structural origin of cooperativity in human hemoglobin: a view from different roles of α and β subunits in the α2β2 tetramer

Nagatomo, Shigenori; Nagai, Masako; Kitagawa, Teizo

doi:10.1007/s12551-022-00945-7

Cited by 7 publications

(5 citation statements)

References 64 publications

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“…Spontaneous magnetization of an array of particles can lead to the appearance of groups with an ordered packing of particles due to the parallel orientation of their magnetic moments. Moving in the vascular bed, such a group represents a soliton-like object [77]- [79]. Since as an object moves due to a change, for example, in the lumen of the vascular bed, its magnetic flux inevitably changes, then, in accordance with the law of electromagnetic induction, electric currents will arise, seeking to compensate for changes in the magnetic flux.…”

Section: Discussionmentioning

confidence: 99%

Interconnections between local Schumann resonances and episodes of kidney disease

Nevoit,

Stankuviene,

Jaruševičius

et al. 2024

J., complex., health sci.

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The aim of the study was to evaluate the interconnections between local Schumann resonances of the Earth’s magnetic field and episodes of kidney disease. Materials and Methods: Study participants included 716 males and 624 females who had episodes of kidney disease during the period of 1 January 2021 to 31 December 2021 and attended the Department of Nephrology at the Hospital of Lithuanian University of Health Sciences, Kauno klinikos. Time varying magnetic field data was collected at the magnetometer site located in Lithuania. Results and Conclusions: The study results support the hypothesis that the Earth’s magnetic field has a relationship between the number of nephrology patient hospitalizations per week and the average weekly local Schumann resonances strength in different frequency ranges. Working hypotheses are proposed for the mechanisms of the influence of the Earth’s electromagnetic field on kidney function: а) quantum mechanical features of the atomic composition of renal tissue molecules determine a kidney-specific reaction; b) cyclotron resonance mechanism; c) resonant response of cells of morphological structures of kidney tissue to external bioactive frequencies in the range of 6-8 Hz; d) mechanism of indirect influence of blood as a magnetically saturated medium.

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Section: Discussionmentioning

confidence: 99%

Interconnections between local Schumann resonances and episodes of kidney disease

Nevoit,

Stankuviene,

Jaruševičius

et al. 2024

J., complex., health sci.

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“…It is interesting that Homo sapiens "inherited" several iron ion-containing molecules via evolution [12], molecules that are essential for several important processes. These include hemoglobin (reviewed in [13,14]), cytochrome P450 enzymes [15][16][17], transferrin [18], ferritin [19], lactoferrin [20] and others [21][22][23][24].…”

Section: Incorporation Of Ferro-magnetic Ions In Essential Systems An...mentioning

confidence: 99%

The Influence of Magnetic Fields, Including the Planetary Magnetic Field, on Complex Life Forms: How Do Biological Systems Function in This Field and in Electromagnetic Fields?

Hart

2024

Biophysica

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Life on Earth evolved to accommodate the biochemical and biophysical boundary conditions of the planet millions of years ago. The former includes nutrients, water, and the ability to synthesize other needed chemicals. The latter includes the 1 g gravity of the planet, radiation, and the geomagnetic field (GMF) of the planet. How complex life forms have accommodated the GMF is not known in detail, considering that Homo sapiens evolved a neurological system, a neuromuscular system, and a cardiovascular system that developed electromagnetic fields as part of their functioning. Therefore, all of these could be impacted by magnetic fields. In addition, many proteins and physiologic processes utilize iron ions, which exhibit magnetic properties. Thus, complex organisms, such as humans, generate magnetic fields, contain significant quantities of iron ions, and respond to exogenous static and electromagnetic fields. Given the current body of literature, it remains somewhat unclear if Homo sapiens use exogenous magnetic fields to regulate function and what can happen if the boundary condition of the GMF no longer exerts an effect. Proposed deep space flights to destinations such as Mars will provide some insights, as space flight could not have been anticipated by evolution. The results of such space flight “experiments” will provide new insights into the role of magnetic fields on human functioning. This review will discuss the literature regarding the involvement of magnetic fields in various normal and disturbed processes in humans while on Earth and then further discuss potential outcomes when the GMF is no longer present to impact host systems, as well as the limitations in the current knowledge. The GMF has been present throughout evolution, but many details of its role in human functioning remain to be elucidated, and how humans have adapted to such fields in order to develop and retain function remains to be elucidated. Why this understudied area has not received the attention required to elucidate the critical information remains a conundrum for both health professionals and those embarking on space flight. However, proposed deep space flights to destinations such as Mars may provide the environments to test and assess the potential roles of magnetic fields in human functioning.

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“…The cooperative response is not only observed in the inter-or intra-cellular networks but also in oligomeric or multimeric proteins and enzymes having more than one ligand-binding subunits [26][27][28][29][30][31][32][33]. The classical example is haemoglobin, an oligomeric protein consisting of four ligand-binding subunits, exhibiting sigmoidal response during oxygen binding [30,33]. Communication among these subunits alter the ligand-binding affinity in successive binding steps which leads to cooperative response [28,29,31,32].…”

Section: Introductionmentioning

confidence: 99%

“…For example, delayed sigmoidal response of the cells is a signature of the cooperative enhancement of the binding tendency of the signaling molecules to the cell receptors [23][24][25]. The cooperative response is not only observed in the inter-or intra-cellular networks but also in oligomeric or multimeric proteins and enzymes having more than one ligand-binding subunits [26][27][28][29][30][31][32][33]. The classical example is haemoglobin, an oligomeric protein consisting of four ligand-binding subunits, exhibiting sigmoidal response during oxygen binding [30,33].…”

Section: Introductionmentioning

confidence: 99%

Elucidating the link between binding statistics and Shannon information in biological cooperative networks

Banerjee,

Das

2024

Preprint

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Cooperative response is ubiquitous and vital for regulatory control and ultra-sensitivity in various cellular biophysical processes. Ligands, acting as signaling molecules, carry information which is transmitted through the elements of the biochemical network during binding processes. In this work, we address a fundamental issue regarding the link between the information content of the various states of the binding network and the observable binding statistics. Two seminal models of cooperativity, viz, the Koshland-Nemethy-Filmer (KNF) network and the Monod-Wyman-Changeux (MWC) network are considered for this purpose which are solved using the chemical master equation approach. Our results establish that the variation of Shannon information associated with the network states has a generic form related to the average binding number. Further, the logarithmic sensitivity of the slope of Shannon information is shown to be related to the Hill slope in terms of the variance of the binding number distributions.

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Structural origin of cooperativity in human hemoglobin: a view from different roles of α and β subunits in the α2β2 tetramer

Cited by 7 publications

References 64 publications

Interconnections between local Schumann resonances and episodes of kidney disease

Interconnections between local Schumann resonances and episodes of kidney disease

The Influence of Magnetic Fields, Including the Planetary Magnetic Field, on Complex Life Forms: How Do Biological Systems Function in This Field and in Electromagnetic Fields?

Elucidating the link between binding statistics and Shannon information in biological cooperative networks

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