This paper introduces the technology and performance of a new sandwich structure consisting of carbon fiber composite face sheets, a polyimide foam core, and an aluminum honeycomb panel with both heat insulation and load-bearing functions. The heat-resistant performance of the sandwich structure was evaluated. The vacuum thermal conductivity of the sandwich structure in the vertical direction ranges from 0.54 to [Formula: see text] with increasing temperature from [Formula: see text] to 135°C. A multilayer finite element model of carbon fiber cloth, polyimide foam, and aluminum honeycomb was established. Finally, a comprehensive evaluation of the mechanical and thermal insulation performance of the sandwich structure was conducted through random vibration testing and thermal vacuum testing. The results showed that the sandwich structure had good stiffness and thermal insulation performance, successfully verifying the effectiveness of the collaborative design.