Structural, spectral, thermal and biological studies on (Z)-N-benzoyl-N′-(2-oxo-2-(phenylamino)acetyl)carbamohydrazonothioic acid (H2PABT) and its Cd(II), Hg(II), Zn(II) and U(VI)O22+ complexes

Antimicrobial and toxicological evaluations of binuclear mercury(ii)bis(alkynyl) complexes containing oligothiophenes and bithiazoles

“…31 The potential antimicrobial properties of metal complexes have been widely explored and investigated. [16][17][18]27,[32][33][34][35][36][37] Among various types of metals, Hg(II) is a highly hazardous element endowed with strong inhibitory activity against microbes. The potential antimicrobial properties of Hg(II) complexes have been widely investigated.…”

“…The potential antimicrobial properties of Hg(II) complexes have been widely investigated. [16][17][18][32][33][34][35][36][37] In this work, the potential antimicrobial property of binuclear Hg(II) bis(alkynyl) complexes bearing oligothiophene and bithiazole conjugated units against MRSA and C. albicans as well as their cytotoxic effect towards NIH 3T3 cells were investigated. The Hg(II) complexes were demonstrated to be active against microorganisms when compared with standard drugs (positive control drugs).…”

“…The Hg(II) complex displayed a slightly better antibacterial effect when compared to the ligand, Cd(II) and Zn(II) complexes (zone of inhibition ranged from 12 AE 0.29 to 15 AE 0.39 mm vs. 9 AE 0.45 to 14 AE 0.33 mm in diameter). 18 Diverse populations of bacteria and fungi colonize the human body when in a healthy state and in a diseased state, and the interactions between these microbial populations can be benecial or harmful to the host. 19 Methicillin-resistant Staphylococcus aureus (MRSA) is a widespread pathogen that causes severe infections acquired both in health-care facilities and in the community.…”

A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells

“…Ligands used for preparation of Cd complexes can be classified as: thiosemicarbazones [16,[18][19][20][21][22][23][24], selenosemicarbazones [25][26][27], hydrazones [16,[27][28][29][30][31][32][33][34][35][36], hydrazides [38,39], diimines [40], amides [41,42], aminoacids [43,44], heterocycles [44][45][46][47][48][49][50][51][52][53][54][55][56], macrocycles [58][59][60], drugs [61][62][63][64], scorpionates [65], natural products …”