Structural sperm and aneuploidies studies in a case of spermatogenesis recovery after the use of androgenic anabolic steroids

Moretti, Elena; Collodel, Giulia; Marca, Antonio La; Piomboni, Paola; Scapigliati, G; Baccetti, Baccio

doi:10.1007/s10815-005-9002-4

Cited by 25 publications

(10 citation statements)

References 7 publications

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“…Immaturity, necrosis and apoptosis were assessed, and a high percentage of structurally normal spermatozoa were found, which showed the absence of a correlation between AAS and ultrastructural sperm changes. In contrast to these findings, FISH sperm analysis revealed XY and chromosomes 1 and 9 disomies, suggesting anomalies in the meiotic process and genetic damage among AAS users [18].…”

Section: The Impact Of Anabolic Steroids On Male Infertility: What Docontrasting

confidence: 69%

Anabolic steroids and male infertility: a comprehensive review

Souza¹,

2011

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What’s known on the subject? and What does the study add? The negative impact of AAS abuse on male fertility is well known by urologists. The secondary hypogonadotropic hypogonadism is often highlighted when AAS and fertility are being discussed. On the other hand, the patterns of use, mechanisms of action and direct effects over the testicle are usually overseen. The present study reviews the vast formal and “underground” culture of AAS, as well as their overall implications. Specific considerations about their impact on the male reproductive system are made, with special attention to the recent data on direct damage to the testicle. To our knowledge this kind of overview is absolutely unique, offering a distinguished set of information to the day‐by‐day urologists. For several decades, testosterone and its synthetic derivatives have been used with anabolic and androgenic purposes. Initially, these substances were restricted to professional bodybuilders, becoming gradually more popular among recreational power athletes. Currently, as many as 3 million anabolic‐androgenic steroids (AAS) users have been reported in the United States, and considering its increasing prevalence, it has become an issue of major concern. Infertility is defined as the failure to achieve a successful pregnancy after 12 months or more of regular unprotected intercourse, with male factor being present in up to 50% of all infertile couples. Several conditions may be related to male infertility. Substance abuse, including AAS, is commonly associated to transient or persistent impairment on male reproductive function, through different pathways. Herein, a brief overview on AAS, specially oriented to urologists, is offered. Steroids biochemistry, patterns of use, physiological and clinical issues are enlightened. A further review about fertility outcomes among male AAS abusers is also presented, including the classic reports on transient axial inhibition, and the more recent experimental reports on structural and genetic sperm damage.

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Section: The Impact Of Anabolic Steroids On Male Infertility: What Docontrasting

confidence: 69%

Anabolic steroids and male infertility: a comprehensive review

Souza¹,

2011

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“…An increased risk of sperm aneuploidy was reported by Moretti et al . () that appeared to remain even after the discontinuation of the steroid abuse, indicating more permanent damage to the chromosome segregation machinery.…”

Section: Sperm Aneuploidy Predictive Factorsmentioning

confidence: 99%

Sperm aneuploidy in infertile male patients: a systematic review of the literature

Chatziparasidou

Christoforidis

Samolada³

et al. 2014

Andrologia

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Males with abnormal karyotypes and subgroups of fertile and infertile males with normal karyotypes may be at risk of producing unbalanced or aneuploid spermatozoa. Biological, clinical, environmental and other factors may also cause additional sperm aneuploidy. However, increased risk of sperm aneuploidy is directly related to chromosomally abnormal embryo production and hence to poor reproductive potential. This systemic literature review focuses on the identification of these males because this is an essential step in the context of assisted reproduction. This research may allow for a more personalised and, hence, more accurate estimation of the risk involved in each case, which in turn will aid genetic counselling for affected couples and help with informed decision-making.

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“…In a study performed on power athletes, it was found that although spermatogenesis could be restored with hCG, sperm morphology and motility continued to be abnormal. Moretti et al 16 used fluorescent in-situ hybridisation for sperm chromosomal analysis after spermatogenesis recovery. A higher frequency of XY disomy and disomies between chromosomes 1 and 9 was identified.…”

Section: Anabolic Androgen Steroidsmentioning

confidence: 99%