2017
DOI: 10.1007/s10930-017-9711-4
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Structural Stability of Streptococcal Serum Opacity Factor

Abstract: Streptococcal serum opacity factor (SOF) is a protein that clouds the plasma of multiple mammalian species by disrupting high density lipoprotein (HDL) structure. Intravenous infusion of low dose SOF (4 μg) into mice reduces their plasma cholesterol concentrations ~40% in 3 h. Here we investigated the effects of pH, ionic strength, temperature, and denaturation with guanidinium chloride (GdmCl) on SOF stability and its reaction vs. HDL. SOF stability was tested by pre-incubation of SOF at various temperatures,… Show more

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