Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)–2,2′:6′,2″‐terpyridine with rigid dianionic 1,2,4‐triazole‐3‐sulfonate linker

Abstract

A new dinuclear coordination compound of palladium(II), [Pd2(terpy)2(μ‐tas‐N1,N4)]SO4⋅11H2O (1), was synthesized by tethering a doubly deprotonated 1,2,4‐triazole‐3‐sulfonate (tas) linker generated in situ via oxidation of 1,2,4‐triazole‐3‐thione (tat) under the synthetic conditions. X‐ray diffraction analysis reveals that tat molecules adopt the thione form in the solid state, and are combined in infinite chains by symmetrically related classical intermolecular hydrogen bonds N1─H1⋅⋅⋅S1, N3─H3⋅⋅⋅N2 to give rise to R22(7) pattern in one‐dimensional chains along the b‐axis propagating along the a‐axis. Further short contacts through lone pairs of N2⋅⋅⋅S1 on the rings between the adjacent chains along the a‐axis lead to a two‐dimensional network structure. Compound 1 was characterized using infrared, 1H NMR and UV–visible spectroscopies, electrospray ionization mass spectrometry and X‐ray crystallography. The crystal structure determination of 1 reveals that the Pd(II) ions are coordinated with four nitrogen atoms: three from terpy and one from tas acting as an end‐to‐end (μ‐1,4) bridging ligand. The Pd(II) ions in 1 adopt a distorted square planar geometry. The anti‐growth effect of 1 was tested on colorectal cancer (HCT‐15), non‐small‐cell lung cancer (A549), prostate cancer (PC‐3) and cervical cancer (HeLa) cell lines using sulforhodamine B viability assay. The cytotoxic effect was further confirmed using adenosine triphosphate viability assay. Compound 1 shows a promising cytotoxic activity in the diverse cancer cell models in vitro (p <0.0001).

Crystal and molecular structures of a binuclear mixed ligand complex of silver(I) with thiocyanate and 1H-1,2,4-triazole-5(4H)-thione

“…Despite the different modes of coordination of the thione-S atoms, the C1-S1 and C3-S2 bond lengths are indistinguishable at 1.698 (3) Å . Each of the C1-S1 and C3-S2 bond lengths in (I) are marginally longer than 1.6836 (19) Å found in the structure of the free molecule (Bü yü kekşi et al, 2018). This small difference is reflected in the observation that no significant differences are evident in bond lengths within the five-membered rings in (I) and those in the uncomplexed molecule (Bü yü kekşi et al, 2018).…”

“…1H-1,2,4-Triazole-5(4H-thione), the heterocyclic ligand in (I) and hereafter referred to as HtrzSH, has attracted relatively little attention in the literature although recently the anti-cancer potential of derivatives of this were described (Bü yü kekşi et al, 2018). The crystallographic study of (I) described herein is complemented by an analysis of the calculated HOMO and LUMO and an analysis of the calculated Hirshfeld surfaces and energy frameworks.…”

Synthesis, Hirshfeld surface analysis, luminescence and thermal properties of three first‐row transition metal complexes containing 4′‐hydroxy‐2,2′:6′,2″‐terpyridine: Application for preparation of nano metal oxides

“…The 2,2 0 :6 0 ,2 00 -terpyridine (tpy) motif and its derivatives are some of the most widely explored tridentate ligands which have widespread use in modern coordination chemistry due to the special coordinative abilities towards some main group elements and most of the d-and f-metals with a broad range of applications such as catalysis, antibacterial and cytotoxic activities, nanoscience and supramolecular chemistry. [1][2][3][4][5][6][7][8][9][10][11][12][13] For example, facile formation of gold(III) acetato, alkoxalato and alkynyl complexes was reported by the direct reaction of gold(III) cation containing terpyridine ligand with corresponding precursors which avoids the gold(III) chloride bond activation pathway commonly employed for access to these functionalities. [14] Terpyridine complexes of transition metals have been much investigated in recent years owing to their potential for the preparation of light-emitting devices and dye-sensitized solar cells.…”