Structurally diverse analgesic diterpenoids from the flowers of Rhododendron molle

Zheng, Guijuan; Huang, Lang; Feng, Yuanyuan; Zhang, Hanqi; Ma, Xiaomin; Gao, Biao; Sun, Yenan; Abudurexiti, Adila; Yao, Guangmin

doi:10.1016/j.fitote.2023.105770

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Compound 4 inhibited the KCNQ2 potassium channel by 38.3% at a concentration of 10 mM. Thirteen novel grayanane diterpenes (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) were isolated from the leaves of R. micranthum, and the structures were identified through extensive spectroscopic analysis and X-ray diffraction [11]. Compound 13 is notable as the first example of a 3α-oxygrayanane diterpenoid glucoside.…”

Section: Overview Of Structural Diversity and Biological Activities O...mentioning

confidence: 99%

“…Despite several reviews that have covered aspects of grayanane diterpenoids, a comprehensive and in-depth overview of the developments and discoveries in this field, especially from 2018 to January 2024, has been lacking [2,6,7,[14][15][16]. This review aims to fill that gap by focusing on the recent advancements made in the isolation, structural elucidation, and bioactivity studies of these diterpenes.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Liu,

Sun,

Zhang

et al. 2024

Molecules

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Diterpenes represent one of the most diverse and structurally complex families of natural products. Among the myriad of diterpenoids, grayanane diterpenes are particularly notable. These terpenes are characterized by their unique 5/7/6/5 tetracyclic system and are exclusive to the Ericaceae family of plants. Renowned for their complex structures and broad spectrum of bioactivities, grayanane diterpenes have become a primary focus in extensive phytochemical and pharmacological research. Recent studies, spanning from 2018 to January 2024, have reported a series of new grayanane diterpenes with unprecedented carbon skeletons. These compounds exhibit various biological properties, including analgesic, antifeedant, anti-inflammatory, and inhibition of protein tyrosine phosphatase 1B (PTP1B). This paper delves into the discovery of 193 newly identified grayanoids, representing 15 distinct carbon skeletons within the Ericaceae family. The study of grayanane diterpenes is not only a deep dive into the complexities of natural product chemistry but also an investigation into potential therapeutic applications. Their unique structures and diverse biological actions make them promising candidates for drug discovery and medicinal applications. The review encompasses their occurrence, distribution, structural features, and biological activities, providing invaluable insights for future pharmacological explorations and research.

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Section: Overview Of Structural Diversity and Biological Activities O...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Liu,

Sun,

Zhang

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

Dauresorcinols A and B, two pairs of merosesquiterpenoid enantiomers with new carbon skeletons from Rhododendron dauricum

Zhang,

Gao,

Zheng

et al. 2024

Bioorganic Chemistry

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Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology

Guo,

Wu,

Ran

et al. 2024

Journal of Ethnopharmacology

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Structurally diverse analgesic diterpenoids from the flowers of Rhododendron molle

Cited by 4 publications

References 22 publications

Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Dauresorcinols A and B, two pairs of merosesquiterpenoid enantiomers with new carbon skeletons from Rhododendron dauricum

Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology

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