Structurally diverse diterpenoids from Isodon ternifolius collected from three regions

Ptp1b Inhibitors From Isodon Ternifolius Collected in Vietnam

“…Isodon species have been reported in previous studies to exhibit various pharmacological activities such as cytotoxic, anti-tumor, anti-inflammatory, antivirus, antibiosis, and anti-proliferative activities [1]. Previous data on chemical constituents of the Isodon genus indicated the presence of phenolics, diterpenoids and triterpenoids [1,[4][5][6][7][8][9][10]. I. ternifolius is rich in diterpenoids [4-7, 9, 10], lignans, and phenylethanoid [8].…”

Ternifolipyrons A–J: new cytotoxic α-pyrones from Isodon ternifolius (D. Don) Kudô

“…2 I. ternifolius (D.Don) Kudô is one of the important traditional herbal plant in traditional Chinese medicine against inammation, icterohepatitis, enteritis, and diarrhoea 2 alongside hepatitis and hepatitis B infection. 5 Several unusual diterpenoids, [6][7][8] lignans, phenylethanoid glycosides, 2 triterpenes, 8 sterols, 9 spiroketones, and avonoids 10 were isolated and identied through chemical characterization of various extracts from distinct I. ternifolius parts. Because of the plant's historic signicance and documented chemical variety, several biological actions of plant extracts and/or metabolites involving anti-cancer activity have been reported [6][7][8]10,11 and the inhibition of DNA topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1).…”

“…All isolates (1-19) were investigated for their growth-inhibitory potential towards CCRF-CEM-leukemia cells at a fixed concentration of 30 mM. The compounds which exerted more than 50% inhibition at this concentration, compounds (7,10,12,(15)(16)(17), were tested at a different concentration range to determine their IC 50 values in CCRF-CEM leukemia, MDA-MB-231 triple-negative breast cancer, and MCF7 breast cancer cell lines. Ursolic acid ( 16) showed the most potent activity against the three cancer cell lines with IC 50 values of 8.37, 18.04, and 18.93 mM, respectively.…”

Anti-Inflammatoryent-Kaurane Diterpenoids fromIsodon serra

“…and comprising approximately 150 species, is mainly distributed in tropical and subtropical Asia . Over the last half a century, a series of phytochemical investigations of this genus have been conducted for its abundant diterpenoid constituents and their various biological activities. − As a result, over 1200 new diterpenoids have been isolated from Isodon plants, − including some ent -kauranoids with excellent antitumor and anti-inflammatory activities, such as oridonin, eriocalyxin B, and isoforretin A …”