Structurally diverse diterpenoids from Isodon oresbius and their bioactivity

New Diterpenes with Potential Antitumoral Activity Isolated from Plants in the Years 2017–2022

“…Further investigations on cell cycle progression, apoptosis, and ROS generation in U937 human leukemia cancer cells showed that compounds 208 and 209 are potent and promising anticancer agents (Figure 83). Isoresbin A 212, with a rearranged 15 (8 → 11)-abeo-6,7-seco-ent-kaurane skeleton, was isolated from Isodon oresbius (W. W. Smith) Kudo (Labiatae), a small shrub distributed on dry hillside rocks or shrubs in China [131] (Figure 84). Extraction was performed with 70% aqueous acetone on the air-dried and powdered aerial parts of I. oresbius and subsequent partitioning with EtOAc and H2O.…”

“…Both compounds had IC50 values <20 M against the HeLa and SW480 cell lines, while compound 213 was also cytotoxic against the A549 and ACHN cell lines, using cisdiaminedichloroplatinum (CDDP) as a positive control. Isoresbin A 212, with a rearranged 15 (8→11)-abeo-6,7-seco-ent-kaurane skeleton, was isolated from Isodon oresbius (W. W. Smith) Kudo (Labiatae), a small shrub distributed on dry hillside rocks or shrubs in China [131] (Figure 84). Extraction was performed with 70% aqueous acetone on the air-dried and powdered aerial parts of I. oresbius and subsequent partitioning with EtOAc and H 2 O.…”

“…Compound 212 showed cytotoxicity against the HeLa, SK-OV-3, SK-HEP-1, Caco2, MDA-MB-231, PC-3, SW480, and A549/Taxol (taxol resistant lung cancer) cell lines, with IC 50 values in the 2.07-14.60 µM range, using the MTS assay, cisplatin, and taxol as positive controls. Isoresbin A 212, with a rearranged 15 (8 → 11)-abeo-6,7-seco-ent-kaurane skeleton, was isolated from Isodon oresbius (W. W. Smith) Kudo (Labiatae), a small shrub distributed on dry hillside rocks or shrubs in China [131] (Figure 84). Extraction was performed with 70% aqueous acetone on the air-dried and powdered aerial parts of I. oresbius and subsequent partitioning with EtOAc and H2O.…”

“…Both compounds had IC50 values <20 M against the HeLa and SW480 cell lines, while compound 213 was also cytotoxic against the A549 and ACHN cell lines, using cisdiaminedichloroplatinum (CDDP) as a positive control. [131] and croyanhuins A 213 and C 214 [132].…”

“…Structurally, the isolates were characterised as 7α,20-epoxy-ent-kaurane diterpenoids. Preliminary structure−activity relationship studies were evaluated, in terms of their in vitro cy- [131] and croyanhuins A 213 and C 214 [132].…”