Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast

Hoshi, Tomoki; Yamada, Keiko; Yoshizawa, Yuko; Oh, Keimei

doi:10.1515/jppr-2015-0051

Cited by 5 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, a large number of studies have been performed to isolate effective chemicals and metabolites. It was also reported that several chemicals including antibiotics can effectively prevent plant diseases caused by bacteria and fungi (Chand et al 1979;McManus et al 2002;Iwai et al 2007;Karthikeyan and Gnanamanickam 2011;Khan et al 2012;Hoshi et al 2015). Therefore, we inferred that human drugs can also have curative effects on plant diseases.…”

Section: Resultsmentioning

confidence: 60%

Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice

Kim¹,

Kwak²,

Song³

et al. 2016

Journal of Plant Protection Research

View full text Add to dashboard Cite

Bacterial leaf blight is one of the major diseases in rice and affects yields. Thus, various methods have been applied to protect rice from this disease. Here, we show systemic translocation of the human drug niclosamide (5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxybenzamide) in rice and its long-term effect on prevention of rice leaf blight. The development of Xanthomonas oryzae pv. oryzae-induced rice leaf blight was effectively inhibited in untreated systemic leaves as in niclosamide-treated leaves, although its effect gradually decreased in a time-dependent manner. Time-course examination after niclosamide treatment showed that the niclosamide level was highest after 3 h in non-treated distal leaves, suggesting fast systemic movement of niclosamide from the treated local site to untreated distal regions. Our data indicate that niclosamide controls rice leaf blight by its rapid systemic movement and that its effect is maintained for a long time.

show abstract

Section: Resultsmentioning

confidence: 60%

Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice

Kim¹,

Kwak²,

Song³

et al. 2016

Journal of Plant Protection Research

View full text Add to dashboard Cite

show abstract

“…The effect of the chlorine atom on the various positions of the phenoxy moiety (ring B) such as 24a, 24b, and 24c can lead to an increase in antifungal activity. As a result, the fungicidal activity of the analogue without a chlorine substituent at ring B (24j) was the most effective against M. oryzae among these compounds ( Figure 22 ) [ 105 ].…”

Section: 124 Triazole Scaffold For the Development Of Antifungal Agentsmentioning

confidence: 99%

Novel 1, 2, 4-Triazoles as Antifungal Agents

Kazeminejad

Marzi

Shiroudi

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4-Triazole is one of the most essential pharmacophore systems between five-membered heterocycles. The structure-activity relationship (SAR) of this nitrogen-containing heterocyclic compound showed potential antifungal activity. The 1,2,4-triazole core is present as the nucleus in a variety of antifungal drug categories. The most potent and broad activity of triazoles have confirmed them as pharmacologically significant moieties. The goal of this review is to highlight recent developments in the synthesis and SAR study of 1,2,4-triazole as a potential fungicidal compound. In this study, we provide the results of a biological activity evaluation using various structures and figures. Literature investigation showed that 1, 2, 4-triazole derivatives reveal the extensive span of antifungal activity. This review will assist researchers in the development of new potential antifungal drug candidates with high effectiveness and selectivity.

show abstract

“…Moreover, the key enzymes in the biosynthesis of brassinosteroids have been evaluated to study their role against Magnaportheoryzae [causing rice blast disease]. It was found that the compound 2RS, 4RS-1-[4-chlorophenyl-(2-methylphenoxy)-ethyl]-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole was a potent antifungal agent against Magnaportheoryzae [113]. Another study reported by Kim et al [114] found that 24-epibrassinolide (EBL) reduced Fusarium wilt in cucumber and enhanced their antioxidant and phenolic levels in roots.…”

Section: Antifungal and Antibacterial Activitiesmentioning

confidence: 99%

Therapeutic Potential of Brassinosteroids in Biomedical and Clinical Research

Kohli

Bhardwaj

et al. 2020

Biomolecules

View full text Add to dashboard Cite

Steroids are a pivotal class of hormones with a key role in growth modulation and signal transduction in multicellular organisms. Synthetic steroids are widely used to cure large array of viral, fungal, bacterial, and cancerous infections. Brassinosteroids (BRs) are a natural collection of phytosterols, which have structural similarity with animal steroids. BRs are dispersed universally throughout the plant kingdom. These plant steroids are well known to modulate a plethora of physiological responses in plants leading to improvement in quality as well as yield of food crops. Moreover, they have been found to play imperative role in stress-fortification against various stresses in plants. Over a decade, BRs have conquered worldwide interest due to their diverse biological activities in animal systems. Recent studies have indicated anticancerous, antiangiogenic, antiviral, antigenotoxic, antifungal, and antibacterial bioactivities of BRs in the animal test systems. BRs inhibit replication of viruses and induce cytotoxic effects on cancerous cell lines. Keeping in view the biological activities of BRs, this review is an attempt to update the information about prospects of BRs in biomedical and clinical application.

show abstract

Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast

Cited by 5 publications

References 23 publications

Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice

Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice

Novel 1, 2, 4-Triazoles as Antifungal Agents

Therapeutic Potential of Brassinosteroids in Biomedical and Clinical Research

Contact Info

Product

Resources

About