Structure-activity relationships in β-adrenoblockers

Yuzhakov, S. D.; Глушков, Р. Г.; Mashkovskii, M. D.

doi:10.1007/bf00772116

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1997

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Cited by 8 publications

(2 citation statements)

References 119 publications

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“…The presence of the amide group may impart certain antiarrhythmic properties; at the same time, the presence of an arylalkylaminoalcohol fragment suggests that the compounds may exhibit 13-adrenoblocking activity [1].…”

mentioning

confidence: 99%

Oxygen-containing heterocycles. Part XVIII. Synthesis and antiarrhythmic activity of N-[1-(1,4-benzodioxan-2-yl)ethyl]amides of N-substituted α-hydroxy-β-aminopropionic acids

et al. 1997

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mentioning

confidence: 99%

Oxygen-containing heterocycles. Part XVIII. Synthesis and antiarrhythmic activity of N-[1-(1,4-benzodioxan-2-yl)ethyl]amides of N-substituted α-hydroxy-β-aminopropionic acids

et al. 1997

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“…Previously we investigated the antiarrhythmic and adrenolytic properties of compounds in which two well-known pharmacophore fragments, 1,4-benzodioxanyl-2-ethyl [1] and a-aminopropanol [2], were linked by various bridging groups, including oxygen (-O-), oximine (=N-O), or amide (-NH-C(O)-). The results confirmed the expediency of the search for new antiarrhythmic drugs among these compounds [3].…”

mentioning

confidence: 99%

Oxygen-containing heterocycles, part xix. Synthesis and antiarrhythmic activity of n′-substituted N-[1-(1,4-benzodioxan-2-yl)ethyl]diaminopropanol dihydrochlorides

et al. 1999

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‘Click Synthesis’ of Some Novel O‐Substituted Oximes Containing 1,2,3‐Triazole‐1,4‐diyl Residues as New Analogs of β‐Adrenoceptor Antagonists

Rad

Behrouz

Karimitabar

et al. 2012

Helvetica Chimica Acta

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The ‘click synthesis’ of some novel O‐substituted oximes, 7a–7t, which contain 1,2,3‐triazolediyl residues, as new analogs of β‐adrenoceptor antagonists is described (Schemes 1–4). The synthesis of these compounds was achieved in four to five steps. The formation of oximes of 9H‐fluoren‐9‐one and benzophenone, i.e., 9a and 9b, respectively, followed by their reaction with propargyl bromide, afforded O‐propargyl oximes 10a and 10b, respectively, which by a subsequent CuI‐catalyzed Huisgen cycloaddition with prepared β‐azido alcohols 11a–11j (Schemes 2 and 3), led to the target compounds 7a–7t in good yields.

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Structure-activity relationships in β-adrenoblockers

Cited by 8 publications

References 119 publications

Oxygen-containing heterocycles. Part XVIII. Synthesis and antiarrhythmic activity of N-[1-(1,4-benzodioxan-2-yl)ethyl]amides of N-substituted α-hydroxy-β-aminopropionic acids

Oxygen-containing heterocycles. Part XVIII. Synthesis and antiarrhythmic activity of N-[1-(1,4-benzodioxan-2-yl)ethyl]amides of N-substituted α-hydroxy-β-aminopropionic acids

Oxygen-containing heterocycles, part xix. Synthesis and antiarrhythmic activity of n′-substituted N-[1-(1,4-benzodioxan-2-yl)ethyl]diaminopropanol dihydrochlorides

‘Click Synthesis’ of Some Novel O‐Substituted Oximes Containing 1,2,3‐Triazole‐1,4‐diyl Residues as New Analogs of β‐Adrenoceptor Antagonists

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