Structure and Anti-Inflammatory Activity Relationship of Ergostanes and Lanostanes in Antrodia cinnamomea

Yang, Xin; Wang, Xiang; Lin, Jiachen; Lim, Sophie Soyeon; Cao, Yujia; Chen, Siyu; Xu, Pingkang; Xu, Chunyuhang; Zheng, Haixue; Fu, Keng-Yen; Kuo, Chien-Liang; Huang, Dejian

doi:10.3390/foods11131831

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Antcin K, an active triterpenoid from the fruiting body of Antrodia camphorata [ 28 ] was analyzed and confirmed by high-performance liquid chromatography (HPLC) detection methods. Antrodia camphorata was identified by external morphology and the marker compound of the plant specimen according to the Taiwan Pharmacopoeia standard.…”

Section: Resultsmentioning

confidence: 99%

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Botanical Antcin K Alleviates High-Fat Damage in Palm Acid Oil-Treated Vascular Endothelial Cells and Macrophages

Nguyen

Shen

et al. 2022

Plants

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Lipid metabolism disorder is the most critical risk factor for atherosclerosis, and the process involves lipid deposition in the arterial intima. In Taiwan, antcin K, an active triterpenoid from the fruiting bodies of Antrodia camphorata, has been considered a potential lipid-lowering agent. Despite this, the possible therapeutic mechanisms of antcin K remain unclear. To explore the crucial role of botanical antcin K in reducing atherosclerotic plaque, we used SVEC4-10 vascular endothelial cells and RAW264.7 macrophages with palm acid oil-induced high-fat damage as our cell models. Our results showed through using the DPPH assay that antcin K had excellent free radical scavenging ability. Antcin K treatment can significantly alleviate the high-fat damage and reduce the levels of inflammatory factors of TNF-α and IL-1β in vascular endothelial cells and macrophages, as shown through MTT assay and ELISA. Furthermore, antcin K treatment can effectively enhance migration ability and clear lipid deposition in macrophages, as shown by using cell migration assay and oil red O staining. When stained with immunofluorescence, antcin K was shown to significantly decrease the expression of adhesion molecules of vascular cell adhesion molecule 1 (VCAM-1) in vascular endothelial cells involved in monocyte migration and inflammation. Antcin K not only reduced the expression of the CD36 scavenger receptor but also augmented the expression of Kruppel-like factor 4 (KLF4) transcription factor in macrophages, which inhibits the transformation of macrophages into foam cells underlying the pathological process of atherosclerosis. Taking our findings into account, we suggested that botanical antcin K could have therapeutic potential for the treatment of atherosclerosis.

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Section: Resultsmentioning

confidence: 99%

“…As shown in Figure 1 , antcin K is an active triterpenoid from the fruiting body of Antrodia camphorata [ 28 ] (Yang et al, 2022). Dried Antrodia camphorata fruiting bodies were ground into a fine powder and extracted with 95% ethanol at ambient temperature by ARJIL Pharmaceuticals.…”

Section: Methodsmentioning

confidence: 99%

Botanical Antcin K Alleviates High-Fat Damage in Palm Acid Oil-Treated Vascular Endothelial Cells and Macrophages

Nguyen

Shen

et al. 2022

Plants

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“…The structures of terpenoids isolated from AC are closely related to the anti-inflammatory activity. The substituents on C15 are crucial to the anti-inflammatory properties of lanostane-type metabolites ( Yang et al, 2022 ).…”

Section: Future Perspectivesmentioning

confidence: 99%

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Li,

Wan,

Qiao

et al. 2024

Front. Pharmacol.

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Prevalent neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and stroke are increasingly becoming a global burden as society ages. It is well-known that degeneration and loss of neurons are the fundamental underlying processes, but there are still no effective therapies for these neurological diseases. In recent years, plenty of studies have focused on the pharmacology and feasibility of natural products as new strategies for the development of drugs that target neurological disorders. Antrodia camphorata has become one of the most promising candidates, and the crude extracts and some active metabolites of it have been reported to play various pharmacological activities to alleviate neurological symptoms at cellular and molecular levels. This review highlights the current evidence of Antrodia camphorata against neurological disorders, including safety evaluation, metabolism, blood-brain barrier penetration, neuroprotective activities, and the potential on regulating the gut-microbiome-brain axis. Furthermore, potential strategies to resolve problematic issues identified in previous studies are also discussed. We aim to provide an overview for the ongoing development and utilization of Antrodia camphorata in cerebral neuropathology.

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“…Antrodia cinnamomea , a basidiomycete that is endemic to Taiwan, is an edible fungus that is a component of many traditional herbal medicines [ 35 , 36 ]. Either crude extracts or molecules isolated from A. cinnamomea have shown diverse biological properties, including antioxidant, anti-tumour, and anti-inflammatory activities [ 37 , 38 ]. Recently, research has shown that dehydroeburicoic acid (DEA) ( 1 ) from A. cinnamomea could inhibit alcoholic fatty liver disease (AFLD) by upregulating aldehyde dehydrogenase 2 family member (ALDH2) activity [ 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease

Cheng

Kuang

et al. 2022

Pharmaceuticals

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Alcoholic liver disease (ALD) is a complicated disease which can lead to hepatocellular carcinoma; however, there is a lack of satisfactory therapeutics. Dehydroeburicoic acid (DEA) (1), a triterpenoid isolated from Antrodia cinnamomea, has been reported to act against ALD, but its mechanisms of action are still not clear. In this study, we report for the first time the use of DEA (1) as a dual inhibitor of the Keap1–Nrf2 protein–protein interaction (PPI) and GSK3β in an in vitro ALD cell model. DEA (1) engages Keap1 to disrupt the Keap1–Nrf2 PPI and inhibits GSK3β to restore Nrf2 activity in a Keap1-independent fashion. DEA (1) promotes Nrf2 nuclear translocation to activate downstream antioxidant genes. Importantly, DEA (1) restores the mitochondrial dysfunction induced by ethanol and generates antioxidant activity in the ALD cell model with minimal toxicity. We anticipate that DEA (1) could be a potential scaffold for the further development of clinical agents for treating ALD.

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Structure and Anti-Inflammatory Activity Relationship of Ergostanes and Lanostanes in Antrodia cinnamomea

Cited by 10 publications

References 22 publications

Botanical Antcin K Alleviates High-Fat Damage in Palm Acid Oil-Treated Vascular Endothelial Cells and Macrophages

Botanical Antcin K Alleviates High-Fat Damage in Palm Acid Oil-Treated Vascular Endothelial Cells and Macrophages

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease

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