Structure and composition of mixed micelles of polymerized and monomeric surfactants

FitzGerald, Paul A.; Chatjaroenporn, Khwanrat; Warr, Gregory G.

doi:10.1016/j.jcis.2015.01.093

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…They can form micelles by molecular plumbing out to hide the hydrophobic segment toward the core and keep the hydrophilic segment on the shell [ 32 ]. These are also known as unimer micelles and are characterized by higher stability compared with conventional micelles [ 33 ]. Mixed micelles are micelles formed by the association of two or more species of amphiphilic compounds.…”

Section: Introductionmentioning

confidence: 99%

Tween 80-Based Self-Assembled Mixed Micelles Boost Valsartan Transdermal Delivery

Yassin,

Massadeh,

Alshwaimi

et al. 2023

Pharmaceuticals

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Valsartan (Val) is an important antihypertensive medication with poor absorption and low oral bioavailability. These constraints are due to its poor solubility and dissolution rate. The purpose of this study was to optimize a mixed micelle system for the transdermal delivery of Val in order to improve its therapeutic performance by providing prolonged uniform drug levels while minimizing drug side effects. Thin-film hydration and micro-phase separation were used to produce Val-loaded mixed micelle systems. A variety of factors, including the surfactant type and drug-to-surfactant ratio, were optimized to produce micelles with a low size and high Val entrapment efficiency (EE). The size, polydispersity index (PDI), zeta potential, and drug EE of the prepared micelles were all measured. The in vitro drug release profiles were assessed using dialysis bags, and the permeation through abdominal rat skin was assessed using a Franz diffusion cell. All formulations had high EE levels exceeding 90% and low particle charges. The micellar sizes ranged from 107.6 to 191.7 nm, with average PDI values of 0.3. The in vitro release demonstrated a uniform slow rate that lasted one week with varying extents. F7 demonstrated a significant (p < 0.01) transdermal efflux of 68.84 ± 3.96 µg/cm2/h through rat skin when compared to the control. As a result, the enhancement factor was 16.57. In summary, Val-loaded mixed micelles were successfully prepared using two simple methods with high reproducibility, and extensive transdermal delivery was demonstrated in the absence of any aggressive skin-modifying enhancers.

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Section: Introductionmentioning

confidence: 99%

Tween 80-Based Self-Assembled Mixed Micelles Boost Valsartan Transdermal Delivery

Yassin,

Massadeh,

Alshwaimi

et al. 2023

Pharmaceuticals

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“…To stabilize the molecular assemblies, polymerizable surfactants have been developed. The polymerizable group is located either in the hydrophobic tail, hydrophilic head group, or counter ion of the polymerizable surfactant and is categorized as T-type, H-type, or C-type, respectively. , These micelles, vesicles, or lyotropic liquid crystals were stabilized by the polymerization of the double bonds in the surfactant structures. − However, in most cases, morphological changes and precipitation occur after polymerization because cross-linkages cause phase transitions prior to the stabilization of the self-assembling structure …”

Section: Introductionmentioning

confidence: 99%

Phase Behavior and Polymerization of the Ternary Polymerizable Cationic Gemini Surfactant/Fatty Alcohol/Water System

et al. 2020

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We studied the phase behavior of a ternary polymerizable gemini surfactant (PC11-6-11)/1-undecanol/water system and stabilized these liquid crystalline structures through the polymerization of surfactants. The addition of 1-undecanol to a PC11-6-11/water system formed bicontinuous cubic (V1) and reversed hexagonal (H2) liquid crystal phases in addition to hexagonal (H1) and lamellar (Lα) phases, which were also formed using the binary system of PC11-6-11/water. These new phases were formed because the fatty alcohol penetrated the palisade layer of the PC11-6-11 micelles. The polymerization of PC11-6-11 with a thermal initiator successfully preserved the Lα and H2 phases. Layered or honeycomb structures of these liquid crystals were clearly observed by transmission electron microscopy. The nanomaterials have potential applications as membranes for nano- or microfiltration and catalyst support materials.

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Rheological properties of wormlike micellar gels formed by novel bio-based isosorbide surfactants

Kamada

Pierlot

Molinier

et al. 2018

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Structure and composition of mixed micelles of polymerized and monomeric surfactants

Cited by 4 publications

References 29 publications

Tween 80-Based Self-Assembled Mixed Micelles Boost Valsartan Transdermal Delivery

Tween 80-Based Self-Assembled Mixed Micelles Boost Valsartan Transdermal Delivery

Phase Behavior and Polymerization of the Ternary Polymerizable Cationic Gemini Surfactant/Fatty Alcohol/Water System

Rheological properties of wormlike micellar gels formed by novel bio-based isosorbide surfactants

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