Structure and Drug Release in a Crosslinked Poly(Ethylene Oxide) Hydrogel

Self-reinforcement and protein sustained delivery of hyaluronan hydrogel by tailoring a dually cross-linked network

“…Similar to the changes in water swelling ratio, the increase of cross-linking density of HA microgels sped up the BSA delivery of srHAs, i.e. srHA-1.5 b srHA-3 b srHA-15, suggesting the swelling property controlled by the cross-linked network was the primary factor of BSA delivery [44]. To understand better the release kinetics and diffusion mechanism of BSA from various HA-based hydrogels, the BSA release data were fit by a semiempirical equation [45,46]:…”

Epoxy networks and hydrogels prepared from α,ω-diamino terminated poly(oxypropylene)-b-poly(oxyethylene)-b-poly(oxypropylene) and polyoxypropylene bis(glycidyl ether)

“…Therefore, the network topology was also reverse, i.e., a single long chain of mutually linked POEBGE molecules is entangled into matrix of D-2000 (POP) chains. 2 Since molar masses of the diamine and diepoxide reagents are not equal, the POE content in the stoichiometric network in this study is 62 wt.% (network E0, see Table 1) unlike 34 wt.% in the corresponding stoichiometric network in the previous study (network R in Table 2, Ref. [24]).…”

“…A number of ways is available for their preparation, e.g., crosslinking of water-soluble polymers in aqueous environment by c-irradiation [1] or swelling of hydrophilic polymer networks in water [2]. A delicate interplay between rubber elasticity of polymer network and polymer-water interaction govern structure and properties of hydrogels which response very sensitively, e.g.…”

Determination of acetaminophen's solubility in poly(ethylene oxide) by rheological, thermal and microscopic methods

“…When APAP concentration is 40%, however, theoretical T g is able to match the experimental value. The hydroxyl group of acetaminophen is a good proton donor and can form strong hydrogen bonds with the oxygen acceptor on the PEO chain (Shekunov et al, 1999(Shekunov et al, , 2007, which is capable of leading to a nonlinear relationship between T g and the composition. Strong intermolecular interaction is usually beneficial for miscibility and solid solution stabilization (Chokshi et al, 2008;Miyazaki et al, 2006;Taylor and Zografi, 1997), but the H-bonding in the current case does not seem to prevent APAP from recrystallizing at room temperature (Yang et al, 2010).…”