On the basis of observations and modelling of the plume generated by the Misa River (AN, Italy), we performed a comprehensive study, which integrated different sources of information (field data, numerical simulations, etc.), of the generation and transport mechanisms of river plumes flowing into microtidal environments. First, we analysed images simultaneously acquired by both two shore-based stations and satellite to determine plume fronts and extensions. Then, we correlated such information with the estuarine forcing to recognize the plume generation and transport mechanisms. Being reallife events influenced by a combination of factors, we run numerical simulations to separately study each force and its influence on the plume evolution. We also performed simulations of two real-life cases, to compare the modelled and observed results. We identified the river discharge and the wind as the main generation and transport mechanisms, respectively. Moreover, waves could stir, suspend, and drag plume sediments, even if results showed that a river discharge associated with a return period smaller than 1 year produced a plume denser than 5-year return period waves. The transport