Structure and function of interleukin-4 and its receptor

Puri, Raj K.

doi:10.1007/978-1-4613-1241-3_6

Cited by 28 publications

(29 citation statements)

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“…Consistent with the pleiotropic nature of this molecule, the receptors for IL-4 have been identified on many different cell types, including hematopoietic and nonhematopoietic cells (19,20,26). A variety of solid cancer cells express a larger number of high-affinity interleukin-4 receptors (IL-4Rs) than do normal cells (14,16,20). These receptors are functional because IL-4 is able to cause signal transduction, inhibit growth of some tumor cell lines, and increase expression of major histocompatibility antigens and intercellular adhesion molecule 1 on tumor cells (11,12,20).…”

Section: Introductionmentioning

confidence: 83%

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Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins

Puri

1999

Toxicol Pathol

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Section: Introductionmentioning

confidence: 83%

“…Because the IL-2Ry chain is also a component of the IL-7, IL-9, and IL-15 receptor systems (2,27,28) (9,11,20). Instead, these cells express the IL-l3Ra' chain and the IL-4R[3 chain (10,11 (24).…”

Section: Introductionmentioning

confidence: 99%

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins

Puri

1999

Toxicol Pathol

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“…[19][20][21][22] The structure of IL-4R has been extensively studied. 23 IL-4Rs are known to exist in 3 different forms in different cell lines. 23 Type 1 IL-4R consists of IL-4R␣ and IL-2R␥ chains, which are predominantly expressed in immune cells.…”

Section: Introductionmentioning

confidence: 99%

“…23 IL-4Rs are known to exist in 3 different forms in different cell lines. 23 Type 1 IL-4R consists of IL-4R␣ and IL-2R␥ chains, which are predominantly expressed in immune cells. Type 2 IL-4R consists of IL-4R␣ and IL-13R␣1 chains, and this type of IL-4R is predominantly expressed in solid tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Hodgkin lymphoma therapy with interleukin-4 receptor–directed cytotoxin in an infiltrating animal model

Kawakami

Kioi

et al. 2005

Blood

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“…[7][8][9][10][11][12][13][14] These pleiotropic effects of IL-4 are mediated through cell-surface receptors. [13][14][15][16] Previous studies have demonstrated that IL-4 receptors are expressed in immune cells and nonimmune cells. [12][13][14] It is noteworthy that human hematopoietic and nonhematopoietic tumor cells overexpress IL-4 receptors on their cell surface.…”

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confidence: 99%

Expression and structure of interleukin 4 receptors in primary meningeal tumors

Puri

Joshi

Sarkar

et al. 2005

Cancer

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BACKGROUNDIt was reported previously that malignant human tumors, like glioma and medulloblastoma, express high‐density interleukin (IL‐4) receptor mRNA and protein. Because IL‐4 receptors (R) are sensitive targets for targeted therapeutics, knowledge of the expression of these receptors in other central nervous system tumors is of great interest. In this study, the authors examined the expression and subunit composition of IL‐4R complex in primary human meningiomas.METHODSReverse transcription‐polymerase chain reaction (RT‐PCR) analysis for IL‐13Rα1, IL‐4Rα and IL‐2Rγc was performed on total RNA extracted from 35 meningiomas and a normal human brain tissue sample. Results were confirmed in nine randomly selected tumors by quantitative real‐time PCR and in situ immunofluorescence assay.RESULTSTranscripts for the IL‐4Rα and IL‐13Rα1 chains were overexpressed in meningiomas compared with normal brain tissue. The levels of IL‐4Rα mRNA appeared to be higher compared with the levels of IL‐13Rα1 mRNA. The results also showed that tumors with higher disease grade tended to have increased mRNA expression for the IL‐4Rα chain. This IL‐4Rα mRNA overexpression appeared to be more frequent in younger patients (age < 37 years). The transcripts for IL‐2Rγc chain were not detected in any of the tumor samples or in normal brain tissue. Quantitative real‐time PCR confirmed the results of the RT‐PCR analysis. Meningiomas also demonstrated a bright immunofluorescent staining for the IL‐4Rα and IL‐13Rα1 chains but no staining for IL‐2Rγc.CONCLUSIONSExpression of the IL‐4Rα and IL‐13Rα1 chains and absence of IL‐2γc expression established that meningiomas expressed type II IL‐4Rs. These receptors may serve as a target for cytotoxin/immunotoxin therapy in patients with meningioma who are not amenable to surgical resection or for recurrent tumors. Cancer 2005. © 2005 American Cancer Society.

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Structure and function of interleukin-4 and its receptor

Cited by 28 publications

References 270 publications

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins

Hodgkin lymphoma therapy with interleukin-4 receptor–directed cytotoxin in an infiltrating animal model

Expression and structure of interleukin 4 receptors in primary meningeal tumors

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