2006
DOI: 10.1634/stemcells.2006-0582
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Structure and Implied Functions of Truncated B-Cell Receptor mRNAs in Early Embryo and Adult Mesenchymal Stem Cells: Cδ Replaces Cμ in μ Heavy Chain-Deficient Mice

Abstract: Stem cells exhibit a promiscuous gene expression pattern.We show herein that the early embryo and adult MSCs express B-cell receptor component mRNAs. To examine possible bearings of these genes on the expressing cells, we studied immunoglobulin chain-deficient mice. Pregnant chain-deficient females were found to produce a higher percentage of defective morulae compared with control females. Structure analysis indicated that the mRNA species found in embryos and in mesenchyme consist of the constant region of t… Show more

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Cited by 4 publications
(1 citation statement)
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“…Stimulation of MSCs with the prototypic Toll-like receptor 2 ligand Pam3Cys has been reported to induce proliferation of MSCs [ 48 ], an effect of the BCR signaling pathway on MSC differentiation and proliferation has not yet been reported. Nevertheless, MSCs express a unique BCR signaling component which leads to G1 growth arrest when transfected into HEK 293T cells [ 49 ]. It can be speculated that the BCR pathway could play an additional role in MSC regulation and their immunomodulatory activities.…”
Section: Discussionmentioning
confidence: 99%
“…Stimulation of MSCs with the prototypic Toll-like receptor 2 ligand Pam3Cys has been reported to induce proliferation of MSCs [ 48 ], an effect of the BCR signaling pathway on MSC differentiation and proliferation has not yet been reported. Nevertheless, MSCs express a unique BCR signaling component which leads to G1 growth arrest when transfected into HEK 293T cells [ 49 ]. It can be speculated that the BCR pathway could play an additional role in MSC regulation and their immunomodulatory activities.…”
Section: Discussionmentioning
confidence: 99%